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Rabbit Anti-FMO5 Recombinant Antibody (CBXF-1127) (CBMAB-F0930-CQ)

This product is a rabbit antibody that recognizes FMO5. The antibody CBXF-1127 can be used for immunoassay techniques such as: WB, IP, IHC-P, IF.
See all FMO5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBXF-1127
Antibody Isotype
IgG
Application
WB, IP, IHC-P, IF

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
flavin containing monooxygenase 5
Introduction
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human2330
Mouse14263
UniProt ID
HumanP49326
MouseP97872
Alternative Names
Flavin Containing Monooxygenase 5; EC 1.14.13.8; Hepatic Flavin-Containing Monooxygenase 5; Dimethylaniline Oxidase 5; FMO 5;
Function
Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (PubMed:28783300, PubMed:26771671, PubMed:20947616).

Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive (PubMed:26771671, PubMed:7872795).

In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) (PubMed:7872795).

Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline (PubMed:28783300).

Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (PubMed:26771671).

Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity).
Biological Process
Drug metabolic process Source: UniProtKB
NADPH oxidation Source: UniProtKB
Regulation of cholesterol metabolic process Source: UniProtKB
Cellular Location
Microsome membrane; Endoplasmic reticulum membrane
Topology
Helical: 513-533
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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