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Rabbit Anti-FOXN3 Recombinant Antibody (CBXF-2254) (CBMAB-F1081-CQ)

This product is a rabbit antibody that recognizes FOXN3. The antibody CBXF-2254 can be used for immunoassay techniques such as: ChIP, FC, IF, WB.
See all FOXN3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXF-2254
Antibody Isotype
IgG
Application
ChIP, FC, IF, WB

Basic Information

Immunogen
Peptides corresponding to Human FOXN3 (aa 381-398, 440-455)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FOXN3
Introduction
This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.
Entrez Gene ID
1112
UniProt ID
O00409
Alternative Names
Forkhead Box N3; Checkpoint Suppressor 1; C14orf116; CHES1; Chromosome 14 Open Reading Frame 116; Forkhead Box Protein N3; PRO1635;
Function
Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
Biological Process
Craniofacial suture morphogenesis Source: Ensembl
Mitotic G2 DNA damage checkpoint signaling Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central
Cellular Location
Nucleus

Zhu, X., Huang, B., Zhao, F., Lian, J., He, L., Zhang, Y., ... & Lin, J. (2023). p38-mediated FOXN3 phosphorylation modulates lung inflammation and injury through the NF-κB signaling pathway. Nucleic Acids Research, gkad057.

Vereczkei, A., Barta, C., Magi, A., Farkas, J., Eisinger, A., Király, O., ... & Kotyuk, E. (2022). FOXN3 and GDNF polymorphisms as common genetic factors of substance use and addictive behaviors. Journal of Personalized Medicine, 12(5), 690.

Chen, X. G., Dou, B. H., An, J. D., Feng, S., Liu, N., & Sheng, G. Y. (2022). MAGI2-AS3 restrains proliferation, glycolysis, and triggers apoptosis in acute lymphoblastic leukemia via regulating miR-452-5p/FOXN3 pathway. Iranian Journal of Basic Medical Sciences, 25(1), 46.

Zhang, J., Hu, Z., Wen, C., Liao, Q., He, B., Peng, J., ... & Xie, Y. (2021). MicroRNA‑182 promotes epithelial‑mesenchymal transition by targeting FOXN3 in gallbladder cancer. Oncology Letters, 21(3), 1-1.

Mo, L., Li, C., Han, S., Zhao, W., & Liu, L. (2020). FOXN3 suppresses the growth and invasion of papillary thyroid cancer through the inactivation of Wnt/β-catenin pathway. Molecular and Cellular Endocrinology, 515, 110925.

Zhang, Z. J., Xiao, Q., & Li, X. Y. (2020). MicroRNA-574-5p directly targets FOXN3 to mediate thyroid cancer progression via Wnt/β-catenin signaling pathway. Pathology-Research and Practice, 216(6), 152939.

Kong, X., Zhai, J., Yan, C., Song, Y., Wang, J., Bai, X., ... & Fang, Y. (2019). Recent advances in understanding FOXN3 in breast cancer, and other malignancies. Frontiers in Oncology, 9, 234.

Sun, M., Ma, X., Tu, C., Wang, X., Qu, J., Wang, S., & Xiao, S. (2019). MicroRNA‐378 regulates epithelial–mesenchymal transition and metastasis of melanoma by inhibiting FOXN3 expression through the Wnt/β‐catenin pathway. Cell Biology International, 43(10), 1113-1124.

Rogers, J. M., Waters, C. T., Seegar, T. C., Jarrett, S. M., Hallworth, A. N., Blacklow, S. C., & Bulyk, M. L. (2019). Bispecific forkhead transcription factor FoxN3 recognizes two distinct motifs with different DNA shapes. Molecular cell, 74(2), 245-253.

Chen, S., Zhang, J., Sun, L., Li, X., Bai, J., Zhang, H., & Li, T. (2019). miR‐611 promotes the proliferation, migration and invasion of tongue squamous cell carcinoma cells by targeting FOXN3. Oral Diseases, 25(8), 1906-1918.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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