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Rabbit Anti-FYCO1 Recombinant Antibody (CBXF-1234) (CBMAB-F1005-CQ)

This product is a rabbit antibody that recognizes FYCO1. The antibody CBXF-1234 can be used for immunoassay techniques such as: WB.
See all FYCO1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1234
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FYVE And Coiled-Coil Domain Containing 1
Introduction
This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2).
Entrez Gene ID
Human79443
Mouse17281
Rat301085
UniProt ID
HumanQ9BQS8
MouseQ8VDC1
RatD3Z9D2
Alternative Names
FYVE And Coiled-Coil Domain Containing 1; Zinc Finger FYVE Domain-Containing Protein 7; ZFYVE7; FYVE And Coiled-Coil Domain-Containing Protein 1; RUN And FYVE Domain Containing 3; CTRCT18; CATC2; RUFY3;
Function
May mediate microtubule plus end-directed vesicle transport.
Biological Process
Plus-end-directed vesicle transport along microtubule Source: UniProtKB
Positive regulation of autophagosome maturation Source: ParkinsonsUK-UCL
Cellular Location
Endosome; Lysosome; Autophagosome. Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.
Involvement in disease
Cataract 18 (CTRCT18):
The disease is caused by variants affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066). An opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.

Khan, S. Y., Ali, M., Kabir, F., Na, C. H., Delannoy, M., Ma, Y., ... & Riazuddin, S. A. (2022). The role of FYCO1-dependent autophagy in lens fiber cell differentiation. Autophagy, 18(9), 2198-2215.

Rudd Garces, G., Christen, M., Loechel, R., Jagannathan, V., & Leeb, T. (2022). FYCO1 frameshift deletion in Wirehaired Pointing Griffon Dogs with juvenile cataract. Genes, 13(2), 334.

Kuhn, C., Menke, M., Senger, F., Mack, C., Dierck, F., Hille, S., ... & Frey, N. (2021). FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo. Basic to Translational Science, 6(4), 365-380.

Satoh, K., Takemura, Y., Satoh, M., Ozaki, K., & Kubota, S. (2021). Loss of FYCO1 leads to cataract formation. Scientific Reports, 11(1), 13771.

Nieto-Torres, J. L., Shanahan, S. L., Chassefeyre, R., Chaiamarit, T., Zaretski, S., Landeras-Bueno, S., ... & Hansen, M. (2021). LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes. Current Biology, 31(15), 3440-3449.

Barashkov, N. A., Konovalov, F. A., Borisova, T. V., Teryutin, F. M., Solovyev, A. V., Pshennikova, V. G., ... & Fedorova, S. A. (2021). Autosomal recessive cataract (CTRCT18) in the Yakut population isolate of Eastern Siberia: a novel founder variant in the FYCO1 gene. European Journal of Human Genetics, 29(6), 965-976.

Xiao, W., Yeerken, D., Li, J., Li, Z., Jiang, L., Li, D., ... & Zhan, Q. (2021). Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1. Signal Transduction and Targeted Therapy, 6(1), 152.

Aprahamian, R., Yammine, T., Salem, N., Souaid, M., Mansour, H., & Farra, C. (2021). Identification of a novel nonsense variant in FYCO1 gene associated with infantile cataract and cortical atrophy. Ophthalmic Genetics, 42(6), 744-746.

Iqbal, H., Khan, S. Y., Zhou, L., Irum, B., Ali, M., Ahmed, M. R., ... & Riazuddin, S. A. (2020). Mutations in FYCO1 identified in families with congenital cataracts. Molecular vision, 26, 334.

Saridaki, T., Nippold, M., Dinter, E., Roos, A., Diederichs, L., Fensky, L., ... & Falkenburger, B. H. (2018). FYCO1 mediates clearance of α‐synuclein aggregates through a Rab7‐dependent mechanism. Journal of neurochemistry, 146(4), 474-492.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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