Rabbit Anti-GPRASP1 Recombinant Antibody (EG1287) (CBMAB-EN1553-LY)

Name: Rabbit Anti-GPRASP1 Recombinant Antibody (EG1287)
SKU: CBMAB-EN1553-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

EG1287

Antibody Isotype

IgG

Application

IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:10000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GASP1.

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

G protein-coupled receptor associated sorting protein 1

Introduction

This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified.

Entrez Gene ID

9737

UniProt ID

Q5JY77

Alternative Names

GASP; GASP1; GASP-1

Function

Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.

Biological Process

Endosome to lysosome transport Source: UniProtKB
G protein-coupled receptor catabolic process Source: UniProtKB

Cellular Location

Cytoplasm

More Infomation

References

Zhang, T., Liu, G., Zhang, J., Chen, S., Deng, Z., & Xie, M. (2023). GPRASP1 is a candidate anti‐oncogene and correlates with immune microenvironment and immunotherapeutic efficiency in head and neck cancer. Journal of Oral Pathology & Medicine, 52(3), 232-244.

Du, J., Chen, Y., Liu, G., Zeng, Q., Zhou, N., & Du, D. (2023). Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer. Pathology-Research and Practice, 243, 154374.

Zeder-Lutz, G., Bornert, O., Fellmann-Clauss, R., Knittel-Obrecht, A., Tranchant, T., Bouteben, S., ... & Simonin, F. (2023). Characterization of anti-GASP motif antibodies that inhibit the interaction between GPRASP1 and G protein-coupled receptors. Analytical Biochemistry, 665, 115062.

Xiong, M., Wang, F., Zhau, H. E., Huang, X., Chung, L., Zhang, J., & Lu, Y. (2019). GPRASP1: A novel potential biomarker for neuroendocrine carcinoma. Cancer Research, 79(13_Supplement), 3295-3295.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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