Mouse Anti-GBP5 Recombinant Antibody (1B2) (CBMAB-G2437-LY)

Name: Mouse Anti-GBP5 Recombinant Antibody (1B2)
SKU: CBMAB-G2437-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1B2

Application

Immunogen

Full length human recombinant protein of human GBP5 (NP_443174) produced in HEK293T cell.ImmunogenType: Recombinant protein

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.7 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Guanylate Binding Protein 5

Introduction

This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

Entrez Gene ID

115362

UniProt ID

Q96PP8

Alternative Names

Guanylate Binding Protein 5; Guanine Nucleotide-Binding Protein 5; GTP-Binding Protein 5; GBP-TA Antigen; GBP-5; Guanylate-Binding Protein 5; EC 3.6.5.-;

Function

As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501).

Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).

Biological Process

Cellular response to interferon-gamma Source: UniProtKB
Inflammatory response Source: UniProtKB-KW
Positive regulation of cytokine production involved in inflammatory response Source: UniProtKB
Positive regulation of innate immune response Source: UniProtKB
Positive regulation of interleukin-18 production Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: UniProtKB
Positive regulation of NLRP3 inflammasome complex assembly Source: UniProtKB
Protein homotetramerization Source: UniProtKB
Protein localization to Golgi apparatus Source: UniProtKB

Cellular Location

Cytoplasm; Golgi apparatus membrane

PTM

Isoprenylation is required for proper subcellular location.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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