Sign in or Register   Sign in or Register
  |  

Mouse Anti-GMPR Recombinant Antibody (3G12) (CBMAB-G4044-LY)

This product is antibody recognizes GMPR. The antibody 3G12 immunoassay techniques such as: ELISA, WB.
See all GMPR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G12
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
GMPR (NP_006868, 1 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Guanosine Monophosphate Reductase
Introduction
This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009]
Entrez Gene ID
2766
UniProt ID
P36959
Alternative Names
Guanosine Monophosphate Reductase; Guanosine 5-Monophosphate Oxidoreductase 1; Guanosine Monophosphate Reductase 1; GMP Reductase 1; EC 1.7.1.7; GMPR 1; GMPR1; Guanine Monophosphate Reductase;
Function
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Biological Process
Purine nucleobase metabolic process Source: UniProtKB-KW
Purine nucleotide metabolic process Source: UniProtKB-UniRule
Response to cold Source: ProtInc
Cellular Location
Cytosol; GMP reductase complex

Gaiya, D. D., Muhammad, A., Aimola, I. A., Udu, S. K., Balarabe, S. A., Auta, R., ... & Sheyin, A. (2023). Potential of Onchocerca ochengi inosine-5′-monophosphate dehydrogenase (IMPDH) and guanosine-5′-monophosphate oxidoreductase (GMPR) as druggable and vaccine candidates: immunoinformatics screening. Journal of Biomolecular Structure and Dynamics, 1-17.

Wolff, D. W., Deng, Z., Bianchi-Smiraglia, A., Foley, C. E., Han, Z., Wang, X., ... & Nikiforov, M. A. (2022). Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro-to anti-oncogenic function of EPHA4. Cell Chemical Biology, 29(6), 970-984.

Knejzlík, Z., Doležal, M., Herkommerová, K., Clarova, K., Klíma, M., Dedola, M., ... & Pichová, I. (2022). The mycobacterial guaB1 gene encodes a guanosine 5′‐monophosphate reductase with a cystathionine‐β‐synthase domain. The FEBS Journal, 289(18), 5571-5598.

Sommerville, E. W., Dalla Rosa, I., Rosenberg, M. M., Bruni, F., Thompson, K., Rocha, M., ... & Gorman, G. S. (2020). Identification of a novel heterozygous guanosine monophosphate reductase (GMPR) variant in a patient with a late‐onset disorder of mitochondrial DNA maintenance. Clinical Genetics, 97(2), 276-286.

Bairagya, H. R., Tasneem, A., Rai, G. P., & Reyaz, S. (2020). Structural and dynamical impact of water molecules at substrate-or product-binding sites in human GMPR enzyme: a study by molecular dynamics simulations. The Journal of Physical Chemistry B, 125(5), 1351-1362.

Rosenberg, M. M., Redfield, A. G., Roberts, M. F., & Hedstrom, L. (2018). Dynamic Characteristics of Guanosine-5′-monophosphate Reductase Complexes Revealed by High-Resolution 31P Field-Cycling NMR Relaxometry. Biochemistry, 57(22), 3146-3154.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-GMPR Recombinant Antibody (3G12)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare