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Mouse Anti-GNG4 Recombinant Antibody (1D9-G11) (CBMAB-G4150-LY)

This product is antibody recognizes GNG4. The antibody 1D9-G11 immunoassay techniques such as: ELISA.
See all GNG4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D9-G11
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
GNG4 (AAH22485, 1 a.a. ~ 75 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
guanine nucleotide binding protein (G protein), gamma 4
Entrez Gene ID
2786
UniProt ID
P50150
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Biological Process
G protein-coupled receptor signaling pathway Source: GO_Central
Negative regulation of cell growth Source: BHF-UCL
Regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Cellular Location
Cell membrane

Jiang, X., Tang, F., Zhang, J., He, M., Xie, T., Tang, H., ... & Wei, Q. (2023). High GNG4 predicts adverse prognosis for osteosarcoma: Bioinformatics prediction and experimental verification. Frontiers in Oncology, 13, 377.

Duan, L., Liu, X., Luo, Z., Zhang, C., Wu, C., Mu, W., ... & Shao, T. (2022). G-protein subunit gamma 4 as a potential biomarker for predicting the response of chemotherapy and immunotherapy in bladder cancer. Genes, 13(4), 693.

Bagchi, S., & Kim, S. (2022). GNG4 is a candidate G-proteinγ-subunit downstream of the Cxcl10/Cxcr3 axis that mediates cell migration in breast cancer. Cancer Research, 82(12_Supplement), 2426-2426.

Tanaka, H., Kanda, M., Miwa, T., Umeda, S., Sawaki, K., Tanaka, C., ... & Kodera, Y. (2021). G-protein subunit gamma-4 expression has potential for detection, prediction and therapeutic targeting in liver metastasis of gastric cancer. British Journal of Cancer, 125(2), 220-228.

Zhu, D., Gu, X., Lin, Z., Yu, D., & Wang, J. (2021). High expression of PSMC2 promotes gallbladder cancer through regulation of GNG4 and predicts poor prognosis. Oncogenesis, 10(5), 43.

Liang, L., Huang, J., Yao, M., Li, L., Jin, X. J., & Cai, X. Y. (2021). GNG4 promotes tumor progression in colorectal cancer. Journal of Oncology, 2021.

Tanaka, H., Kanda, M., Miwa, T., Umeda, S., Sawaki, K., Tanaka, C., ... & Kodera, Y. (2020). G protein subunit gamma 4 expression has potential of detection, prediction, and therapeutic target for liver metastasis of gastric cancer. medRxiv, 2020-08.

Kishibuchi, R., Kondo, K., Soejima, S., Tsuboi, M., Kajiura, K., Kawakami, Y., ... & Tangoku, A. (2020). DNA methylation of GHSR, GNG4, HOXD9 and SALL3 is a common epigenetic alteration in thymic carcinoma. International Journal of Oncology, 56(1), 315-326.

Song, J., Yang, J., Lin, R., Cai, X., Zheng, L., & Chen, Y. (2020). Molecular heterogeneity of guanine nucleotide binding‑protein γ subunit 4 in left‑and right‑sided colon cancerCorrigendum in/10.3892/ol. 2021.12488 Corrigendum in/10.3892/ol. 2022.13597. Oncology Letters, 20(6), 1-1.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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