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Mouse Anti-GNRHR Recombinant Antibody (CBYJL-155) (CBMAB-L0232-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Gonadotropin Releasing Hormone Receptor (GNRHR). The antibody can be used for immunoassay techniques, such as IHC-P, IF, ICC, FC.
See all GNRHR antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBYJL-155
Antibody Isotype
IgG1, κ
Application
IHC-P, IF, ICC, FC

Basic Information

Immunogen
A synthetic peptide aa 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRH receptor.
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-29

Target

Full Name
gonadotropin releasing hormone receptor
Introduction
GNRHR is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. GNRHR is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of GNRHR ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.
Entrez Gene ID
Human2798
Rat81668
UniProt ID
HumanP30968
RatP30969
Alternative Names
Gonadotropin Releasing Hormone Receptor; Gonadotropin-Releasing Hormone Receptor; GnRH Receptor; GnRH-R; GRHR; Gonadotropin-Releasing Hormone (Type 1) Receptor 1; Leutinizing Hormone Releasing Horomone Receptor; Leutinizing-Releasing Hormone Receptor
Function
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
Biological Process
G protein-coupled receptor signaling pathway Source: GO_Central
Multicellular organism development Source: ProtInc
Cellular Location
Cell membrane
Involvement in disease
Hypogonadotropic hypogonadism 7 with or without anosmia (HH7):
The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in GNRHR as well as in other HH-associated genes including FGFR1 (PubMed:23643382). A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Topology
Extracellular: 1-38
Helical: 39-58
Cytoplasmic: 59-77
Helical: 78-97
Extracellular: 98-115
Helical: 116-137
Cytoplasmic: 138-164
Helical: 165-184
Extracellular: 185-212
Helical: 213-232
Cytoplasmic: 233-281
Helical: 282-300
Extracellular: 301-306
Helical: 307-326
Cytoplasmic: 327-328

Šmigoc Schweiger, D., Davidović Povše, M., Trebušak Podkrajšek, K., Battelino, T., & Avbelj Stefanija, M. (2022). GNRHR-related central hypogonadism with spontaneous recovery–case report. Italian Journal of Pediatrics, 48(1), 1-5.

Odle, A. K., MacNicol, M. C., Childs, G. V., & MacNicol, A. M. (2021). Post-transcriptional regulation of Gnrhr: A checkpoint for metabolic control of female reproduction. International Journal of Molecular Sciences, 22(7), 3312.

Lidaka, L., Bekere, L., Rota, A., Isakova, J., Lazdane, G., Kivite-Urtane, A., ... & Gailite, L. (2021). Role of single nucleotide variants in FSHR, GNRHR, ESR2 and LHCGR Genes in adolescents with polycystic ovary syndrome. Diagnostics, 11(12), 2327.

Maione, L., Fèvre, A., Nettore, I. C., Manilall, A., Francou, B., Trabado, S., ... & Young, J. (2019). Similarities and differences in the reproductive phenotypes of women with congenital hypogonadotrophic hypogonadism caused by GNRHR mutations and women with polycystic ovary syndrome. Human Reproduction, 34(1), 137-147.

Kim, J. W., Yadav, D. K., Kim, S. J., Lee, M. Y., Park, J. M., Kim, B. S., ... & Kang, K. W. (2019). Anti-cancer effect of GV1001 for prostate cancer: function as a ligand of GnRHR. Endocrine-related cancer, 26(2), 147-162.

Cioppi, F., Riera‐Escamilla, A., Manilall, A., Guarducci, E., Todisco, T., Corona, G., ... & Krausz, C. (2019). Genetics of ncHH: from a peculiar inheritance of a novel GNRHR mutation to a comprehensive review of the literature. Andrology, 7(1), 88-101.

Elokil, A. A., Bhuiyan, A. A., Liu, H. Z., Hussein, M. N., Ahmed, H. I., Azmal, S. A., ... & Li, S. (2019). The capability of L-carnitine-mediated antioxidant on cock during aging: evidence for the improved semen quality and enhanced testicular expressions of GnRH1, GnRHR, and melatonin receptors MT 1/2. Poultry Science, 98(9), 4172-4181.

Odle, A. K., Beneš, H., Melgar Castillo, A., Akhter, N., Syed, M., Haney, A., ... & Childs, G. V. (2018). Association of Gnrhr mRNA with the stem cell determinant Musashi: a mechanism for leptin-mediated modulation of GnRHR expression. Endocrinology, 159(2), 883-894.

Bemji, M. N., Isa, A. M., Ibeagha-Awemu, E. M., & Wheto, M. (2018). Polymorphisms of caprine GnRHR gene and their association with litter size in West African Dwarf goats. Molecular biology reports, 45, 63-69.

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For research use only. Not intended for any clinical use.

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