Mouse Anti-GOLGA5 Monoclonal Antibody (6B3) (CBMAB-1336-YC)

Name: Mouse Anti-GOLGA5 Monoclonal Antibody (6B3)
SKU: CBMAB-1336-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6B3

Application

ELISA, WB

Immunogen

Partial recombinant protein GOLGA5 (NP_005104, aa 2-100) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Golgin A5

Introduction

GOLGA5 is one of the golgins, a family of proteins localized to the Golgi. GOLGA5 is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving GOLGA5 and the ret proto-oncogene have been found in tumor tissues.

Entrez Gene ID

9950

UniProt ID

Q8TBA6

Alternative Names

RFG5; GOLIM5; ret-II

Function

Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

Biological Process

Golgi organization Source: UniProtKB
Golgi vesicle transport Source: UniProtKB
Retrograde transport, vesicle recycling within Golgi Source: GO_Central

Cellular Location

Golgi apparatus membrane. Found throughout the Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network.

Involvement in disease

A chromosomal aberration involving GOLGA5 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene.

Topology

Cytoplasmic: 2-698
Helical: 699-719
Lumenal: 720-731

PTM

Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase.

Asensio, C. S. (2020). 253-LB: A Novel Membrane Binding Domain in Conjunction with Golga5 Recruits the Secretory Granule Biogenesis Factor HID-1 to the Golgi. Diabetes, 69(Supplement_1).

Ding, Y. Y., Stern, J. W., Jubelirer, T. F., Wertheim, G. B., Lin, F., Chang, F., ... & Tasian, S. K. (2018). Clinical efficacy of ruxolitinib and chemotherapy in a child with Philadelphia chromosome-like acute lymphoblastic leukemia with GOLGA5-JAK2 fusion and induction failure. Haematologica, 103(9), e427-e431.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

GOLGA5 Matched Antibody Pair (492) (CAT#: APMAB-492LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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