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Mouse Anti-GOLM1 Recombinant Antibody (2D6) (CBMAB-G4311-LY)

This product is antibody recognizes GOLM1. The antibody 2D6 immunoassay techniques such as: FC.
See all GOLM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D6
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
GOLM1 antibody was raised in mouse using a full length recombinant protein of human GOLM1 (NP_808800) produced in HEK293T cells, as the immunogen
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol, 1% BSA
Preservative
0.02% sodium azide
Concentration
0.5 mg-1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Golgi Membrane Protein 1
Introduction
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]
Entrez Gene ID
UniProt ID
Alternative Names
Golgi Membrane Protein 1; Golgi Phosphoprotein 2; Golgi Membrane Protein GP73; C9orf155; GOLPH2; Chromosome 9 Open Reading Frame 155; Epididymis Luminal Protein 46;
Function
Unknown. Cellular response protein to viral infection.
Biological Process
Nucleus organization Source: Ensembl
Regulation of lipid metabolic process Source: Ensembl
Cellular Location
Cis-Golgi network membrane. Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.
Topology
Cytoplasmic: 1-12
Helical: 13-35
Lumenal: 36-401
PTM
Glycosylated.
Phosphorylation sites are present in the extracellular medium.

Shao, W. Q., Zhu, W. W., Luo, M. J., Fan, M. H., Li, Q., Wang, S. H., ... & Qin, L. X. (2022). Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma. Cell Reports, 39(3), 110712.

Sun, Z., Mao, Y., Zhang, X., Lu, S., Wang, H., Zhang, C., ... & Li, K. (2021). Identification of ARHGEF38, NETO2, GOLM1, and SAPCD2 associated with prostate cancer progression by bioinformatic analysis and experimental validation. Frontiers in Cell and Developmental Biology, 9, 718638.

Chen, J., Lin, Z., Liu, L., Zhang, R., Geng, Y., Fan, M., ... & Qin, L. X. (2021). GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages. Signal transduction and targeted therapy, 6(1), 397.

Pu, Y., Song, Y., Zhang, M., Long, C., Li, J., Wang, Y., ... & Zhang, H. (2021). GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis. Signal Transduction and Targeted Therapy, 6(1), 148.

Yan, J., Zhou, B., Li, H., Guo, L., & Ye, Q. (2020). Recent advances of GOLM1 in hepatocellular carcinoma. Hepatic oncology, 7(2), HEP22.

Yan, J., Zhou, B., Guo, L., Chen, Z., Zhang, B., Liu, S., ... & Ye, Q. (2020). GOLM1 upregulates expression of PD-L1 through EGFR/STAT3 pathway in hepatocellular carcinoma. American journal of cancer research, 10(11), 3705.

Lin, Y., Dong, H., Deng, W., Lin, W., Li, K., Xiong, X., ... & Zhang, H. (2019). Evaluation of Salivary Exosomal Chimeric GOLM1-NAA35 RNA as a Potential Biomarker in Esophageal CarcinomaExosomal Chimeric RNA in Cancer. Clinical Cancer Research, 25(10), 3035-3045.

Teerlink, C. C., Huff, C., Stevens, J., Yu, Y., Holmen, S. L., Silvis, M. R., ... & Cannon-Albright, L. A. (2018). A nonsynonymous variant in the GOLM1 gene in cutaneous malignant melanoma. JNCI: Journal of the National Cancer Institute, 110(12), 1380-1385.

Yan, G., Ru, Y., Wu, K., Yan, F., Wang, Q., Wang, J., ... & Zou, L. (2018). GOLM1 promotes prostate cancer progression through activating PI3K‐AKT‐mTOR signaling. The Prostate, 78(3), 166-177.

Yang, L., Luo, P., Song, Q., & Fei, X. (2018). DNMT1/miR-200a/GOLM1 signaling pathway regulates lung adenocarcinoma cells proliferation. Biomedicine & Pharmacotherapy, 99, 839-847.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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