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Mouse Anti-GOT2 Recombinant Antibody (CBLG1-1551) (CBMAB-G4428-LY)

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Basic Information

Host Animal
Mouse
Clone
CBLG1-1551
Application
WB
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.02% Proclin 300
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
glutamic-oxaloacetic transaminase 2
Introduction
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Entrez Gene ID
Human2806
Mouse14719
UniProt ID
HumanP00505
MouseP05202
Function
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
Biological Process
2-oxoglutarate metabolic process Source: UniProtKB
4-hydroxyproline catabolic process Source: BHF-UCL
Aspartate biosynthetic process Source: Ensembl
Aspartate catabolic process Source: UniProtKB
Aspartate metabolic process Source: UniProtKB
Fatty acid transport Source: UniProtKB
Female pregnancy Source: Ensembl
Glutamate catabolic process to 2-oxoglutarate Source: Ensembl
Glutamate catabolic process to aspartate Source: Ensembl
Glutamate metabolic process Source: UniProtKB
Lactation Source: Ensembl
Oxaloacetate metabolic process Source: Ensembl
Response to ethanol Source: UniProtKB
Response to insulin Source: Ensembl
Response to morphine Source: Ensembl
Response to muscle activity Source: Ensembl
Cellular Location
Mitochondrion matrix; Cell membrane. Exposure to alcohol promotes translocation to the cell membrane.
Involvement in disease
Developmental and epileptic encephalopathy 82 (DEE82):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE82 is an autosomal recessive metabolic encephalopathy characterized by epilepsy from the first year of life, global developmental delay, hypotonia and feeding difficulties apparent soon after birth, and intellectual and motor disabilities. Other features include poor overall growth, progressive microcephaly and biochemical abnormalities, including increased serum lactate and ammonia.

Abrego, J., Sanford-Crane, H., Oon, C., Xiao, X., Betts, C. B., Sun, D., ... & Sherman, M. H. (2022). A cancer cell–intrinsic GOT2–PPARδ axis suppresses antitumor immunity. Cancer discovery, 12(10), 2414-2433.

Nwosu, Z. C., & Pasca di Magliano, M. (2022). GOT2: An Unexpected Mediator of Immunosuppression in Pancreatic Cancer. Cancer Discovery, 12(10), 2237-2239.

Yao, Q., Wang, C., Wang, Y., Xiang, W., Chen, Y., Zhou, Q., ... & Chen, D. (2022). STXBP3 and GOT2 predict immunological activity in acute allograft rejection. Frontiers in Immunology, 13, 1025681.

Ferreira, W. A. S., & de Oliveira, E. H. C. (2022). Expression of GOT2 Is Epigenetically Regulated by DNA Methylation and Correlates with Immune Infiltrates in Clear-Cell Renal Cell Carcinoma. Current Issues in Molecular Biology, 44(6), 169.

Hickman, T. L., Choi, E., Whiteman, K. R., Muralidharan, S., Pai, T., Johnson, T., ... & Jensen-Smith, A. (2021). BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved antitumor activity. bioRxiv, 2021-11.

Guan, H., Sun, C., Gu, Y., Li, J., Ji, J., & Zhu, Y. (2021). Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer. Bioengineered, 12(1), 2326-2340.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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