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Rat Anti-GPA33 Recombinant Antibody (CBYC-A965) (CBMAB-A4433-YC)

Provided herein is a Rat monoclonal antibody against Human Glycoprotein A33. The antibody can be used for immunoassay techniques, such as WB, FC, IHC, CyTOF.
See all GPA33 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
CBYC-A965
Antibody Isotype
IgG2a
Application
WB, FC, IHC, CyTOF

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human A33, Ile22-Val235.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized from PBS with trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glycoprotein A33
Introduction
The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosyla
Entrez Gene ID
10223
UniProt ID
Q99795
Alternative Names
Glycoprotein A33; Glycoprotein A33 (Transmembrane); Transmembrane Glycoprotein A33; Cell Surface A33 Antigen; A33;
Function
May play a role in cell-cell recognition and signaling.
Cellular Location
Membrane
Topology
Extracellular: 22-235
Helical: 236-256
Cytoplasmic: 257-319
PTM
N-glycosylated, contains approximately 8 kDa of N-linked carbohydrate.
Palmitoylated.

Börding, T., Janik, T., Morkel, M., Sers, C., & Horst, D. (2023). Tumor cell heterogeneity may cause treatment failure of GPA33-targeted therapy in colorectal cancer. Cancer Research, 83(7_Supplement), 6227-6227.

Opstelten, R., Suwandi, J. S., Slot, M. C., Morgana, F., Scott, A. M., Laban, S., ... & Amsen, D. (2021). GPA33 is expressed on multiple human blood cell types and distinguishes CD4+ central memory T cells with and without effector function. European journal of immunology, 51(6), 1377-1389.

Chandler, C., Cheal, S., Nash, G., Cercek, A., McDevitt, M., Xu, H., ... & Larson, S. (2020). Pretargeted Radioimmunotherapy using 225Ac for Intraperitoneal GPA33-Expressing Colorectal Xenografts.

Wei, D., Tao, Z., Shi, Q., Wang, L., Liu, L., She, T., ... & Jiang, X. (2020). Selective photokilling of colorectal tumors by near-infrared photoimmunotherapy with a GPA33-targeted single-chain antibody variable fragment conjugate. Molecular Pharmaceutics, 17(7), 2508-2517.

Lopes, N., Bergsland, C., Bruun, J., Bjørnslett, M., Vieira, A. F., Mesquita, P., ... & David, L. (2020). A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis. Gastric Cancer, 23, 811-823.

Chandler, C., Cheal, S., Nash, G., Cercek, A., Punzalan, B., Veach, D., ... & Cheung, N. K. (2020). Multicycle pretargeted radioimmunotherapy using 177Lu for intraperitoneal GPA33-expressing colorectal xenografts.

Lopes, N., Bergsland, C., Bjornslett, M., Bruun, J., Lothe, R., Almeida, R., & David, L. (2018). CDX2 targets, GPA33 and LI-cadherin, are novel biomarkers with prognostic value in gastric cancer. Cancer Research, 78(13_Supplement), 565-565.

Moore, P. A., Shah, K., Yang, Y., Alderson, R., Roberts, P., Long, V., ... & Johnson, S. (2018). Development of MGD007, a gpA33 x CD3-bispecific DART protein for T-cell immunotherapy of metastatic colorectal cancer. Molecular Cancer Therapeutics, 17(8), 1761-1772.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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