Mouse Anti-GPD2 Recombinant Antibody (2C11-1F4) (CBMAB-G4540-LY)

This product is antibody recognizes GPD2. The antibody 2C11-1F4 immunoassay techniques such as: ELISA, WB.
See all GPD2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2C11-1F4

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

glycerol-3-phosphate dehydrogenase 2 (mitochondrial)

Introduction

The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]

Entrez Gene ID

2820

UniProt ID

P43304

Alternative Names

Glycerol-3-Phosphate Dehydrogenase 2; Glycerol-3-Phosphate Dehydrogenase 2 (Mitochondrial); EC 1.1.5.3; GPDH-M; GPD-M; MtGPD; Glycerol-3-Phosphate Dehydrogenase; Mitochondrial;

Function

Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

Biological Process

Glycerol-3-phosphate metabolic process Source: InterPro
Glycerol catabolic process Source: UniProtKB-UniPathway
Glycerophosphate shuttle Source: Reactome

Cellular Location

Mitochondrion

References

Wu, S., Mao, C., Kondiparthi, L., Poyurovsky, M. V., Olszewski, K., & Gan, B. (2022). A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria. Proceedings of the National Academy of Sciences, 119(26), e2121987119.

Ishihama, S., Yoshida, S., Yoshida, T., Mori, Y., Ouchi, N., Eguchi, S., ... & Takefuji, M. (2021). LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia. The FASEB Journal, 35(12), e22048.

Lu, J., Xu, Z., Duan, H., Ji, H., Zhen, Z., Li, B., ... & Zhang, R. (2020). Tumor‐associated macrophage interleukin‐β promotes glycerol‐3‐phosphate dehydrogenase activation, glycolysis and tumorigenesis in glioma cells. Cancer Science, 111(6), 1979-1990.

Langston, P. K., Nambu, A., Jung, J., Shibata, M., Aksoylar, H. I., Lei, J., ... & Horng, T. (2019). Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nature immunology, 20(9), 1186-1195.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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