Rabbit Anti-GPR142 Recombinant Antibody (EG1377) (CBMAB-EN1656-LY)

Name: Rabbit Anti-GPR142 Recombinant Antibody (EG1377)
SKU: CBMAB-EN1656-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1377

Application

WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GPR142.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

G Protein-Coupled Receptor 142

Introduction

GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

Entrez Gene ID

350383

UniProt ID

Q7Z601

Alternative Names

G Protein-Coupled Receptor 142; G-Protein Coupled Receptor PGR2; PGR2; G-Protein Coupled Receptor 142 Long Form; Probable G-Protein Coupled Receptor 142; GPRg1b;

Function

Orphan receptor.

Cellular Location

Cell membrane

Topology

Extracellular: 1-152
Helical: 153-173
Cytoplasmic: 174-195
Helical: 196-216
Extracellular: 217-233
Helical: 234-254
Cytoplasmic: 255-278
Helical: 279-299
Extracellular: 300-316
Helical: 317-337
Cytoplasmic: 338-357
Helical: 358-378
Extracellular: 379-397
Helical: 398-418
Cytoplasmic: 419-462

Barella, L. F., Jain, S., Kimura, T., & Pydi, S. P. (2021). Metabolic roles of G protein‐coupled receptor signaling in obesity and type 2 diabetes. The FEBS journal, 288(8), 2622-2644.

Kurtz, R., Anderman, M. F., & Shepard, B. D. (2021). GPCRs get fatty: The role of G protein-coupled receptor signaling in the development and progression of nonalcoholic fatty liver disease. American Journal of Physiology-Gastrointestinal and Liver Physiology, 320(3), G304-G318.

Kaushik, A. C., Mehmood, A., Dai, X., & Wei, D. Q. (2021). Pan-cancer Analysis and Drug Formulation for GPR139 and GPR142. Frontiers in Pharmacology, 11, 521245.

Pratt, E. J., Oura, T., Ma, X., Lin, H. V., Ma, T., Efanov, A. M., & Thomas, M. K. (2019). 20-OR: GPR142 agonists increase glucose-dependent insulin secretion and differentially regulate hormone secretion in preclinical and phase 1 studies. Diabetes, 68(Supplement_1).

Al-Amily, I. M., Dunér, P., Groop, L., & Salehi, A. (2019). The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent. Pflügers Archiv-European Journal of Physiology, 471, 633-645.

Kaushik, A. C., Mao, X., Li, C. D., Li, Y., Wei, D. Q., & Sahi, S. (2019). G-protein-coupled receptors function as logic gates for nanoparticle binding using systems and synthetic biology approach. Journal of Materials Research, 34(11), 1854-1867.

Kaushik, A. C., Kumar, S., Wei, D. Q., & Sahi, S. (2018). Structure based virtual screening studies to identify novel potential compounds for GPR142 and their relative dynamic analysis for study of type 2 diabetes. Frontiers in chemistry, 6, 23.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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