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Rabbit Anti-GPR142 Recombinant Antibody (EG1377) (CBMAB-EN1656-LY)

The product is antibody recognizes GPR142. The antibody EG1377 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000.
See all GPR142 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1377
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GPR142.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G Protein-Coupled Receptor 142
Introduction
GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
350383
UniProt ID
Q7Z601
Alternative Names
G Protein-Coupled Receptor 142; G-Protein Coupled Receptor PGR2; PGR2; G-Protein Coupled Receptor 142 Long Form; Probable G-Protein Coupled Receptor 142; GPRg1b;
Function
Orphan receptor.
Cellular Location
Cell membrane
Topology
Extracellular: 1-152
Helical: 153-173
Cytoplasmic: 174-195
Helical: 196-216
Extracellular: 217-233
Helical: 234-254
Cytoplasmic: 255-278
Helical: 279-299
Extracellular: 300-316
Helical: 317-337
Cytoplasmic: 338-357
Helical: 358-378
Extracellular: 379-397
Helical: 398-418
Cytoplasmic: 419-462

Barella, L. F., Jain, S., Kimura, T., & Pydi, S. P. (2021). Metabolic roles of G protein‐coupled receptor signaling in obesity and type 2 diabetes. The FEBS journal, 288(8), 2622-2644.

Kurtz, R., Anderman, M. F., & Shepard, B. D. (2021). GPCRs get fatty: The role of G protein-coupled receptor signaling in the development and progression of nonalcoholic fatty liver disease. American Journal of Physiology-Gastrointestinal and Liver Physiology, 320(3), G304-G318.

Kaushik, A. C., Mehmood, A., Dai, X., & Wei, D. Q. (2021). Pan-cancer Analysis and Drug Formulation for GPR139 and GPR142. Frontiers in Pharmacology, 11, 521245.

Pratt, E. J., Oura, T., Ma, X., Lin, H. V., Ma, T., Efanov, A. M., & Thomas, M. K. (2019). 20-OR: GPR142 agonists increase glucose-dependent insulin secretion and differentially regulate hormone secretion in preclinical and phase 1 studies. Diabetes, 68(Supplement_1).

Al-Amily, I. M., Dunér, P., Groop, L., & Salehi, A. (2019). The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent. Pflügers Archiv-European Journal of Physiology, 471, 633-645.

Kaushik, A. C., Mao, X., Li, C. D., Li, Y., Wei, D. Q., & Sahi, S. (2019). G-protein-coupled receptors function as logic gates for nanoparticle binding using systems and synthetic biology approach. Journal of Materials Research, 34(11), 1854-1867.

Kaushik, A. C., Kumar, S., Wei, D. Q., & Sahi, S. (2018). Structure based virtual screening studies to identify novel potential compounds for GPR142 and their relative dynamic analysis for study of type 2 diabetes. Frontiers in chemistry, 6, 23.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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