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Rabbit Anti-GPR146 Recombinant Antibody (EG1380) (CBMAB-EN1659-LY)

The product is antibody recognizes GPR146. The antibody EG1380 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:5000.
See all GPR146 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1380
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:5000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GPR146.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G protein-coupled receptor 146
Entrez Gene ID
UniProt ID
Alternative Names
PGR8
Function
Orphan receptor.
Cellular Location
Cell membrane
Topology
Extracellular: 1-30
Helical: 31-51
Cytoplasmic: 52-65
Helical: 66-86
Extracellular: 87-102
Helical: 103-123
Cytoplasmic: 124-146
Helical: 147-167
Extracellular: 168-189
Helical: 190-210
Cytoplasmic: 211-233
Helical: 234-254
Extracellular: 255-279
Helical: 280-300
Cytoplasmic: 301-333

Al Mahri, S., Okla, M., Rashid, M., Malik, S. S., Iqbal, J., Al Ibrahim, M., ... & Mohammad, S. (2023). Profiling of G-protein Coupled Receptors in Adipose Tissue and Differentiating Adipocytes Offers a Translational Resource for Obesity/Metabolic Research. Cells, 12(3), 377.

Wilkins, B. P., Finch, A. M., Wang, Y., & Smith, N. J. (2022). Orphan GPR146: an alternative therapeutic pathway to achieve cholesterol homeostasis?. Trends in Endocrinology & Metabolism.

Bray, L., Caillaud, A., Girardeau, A., Patitucci, M., Le May, C., Cariou, B., & Rimbert, A. (2022). Generation of a GPR146 knockout human induced pluripotent stem cell line (ITXi001-A-1). Stem Cell Research, 60, 102721.

Rimbert, A., Yeung, M. W., Dalila, N., Thio, C. H., Yu, H., Loaiza, N., ... & Kuivenhoven, J. A. (2022). Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile. Arteriosclerosis, thrombosis, and vascular biology, 42(10), 1262-1271.

Loaiza, N. (2022). Functional Insights Into Novel Regulators of Plasma Lipids: STAP1 and GPR146.

Brachs, S., Mai, K., Sbierski-Kind, J., Klockgeter, J., Harutyunyan, A., Liu, A., ... & Spranger, J. (2022). A metabolically-healthy lean phenotype is sustained in GPR146-deficient mice during diet-induced obesity. Diabetologie und Stoffwechsel, 17(S 01), P-100.

Fernández-Ruiz, I. (2020). GPR146 is a potential new therapeutic target for lipid lowering. Nature Reviews Cardiology, 17(3), 132-133.

She, L., Yao, H., He, L., Li, Y., & Cao, J. (2020). GPR146: an emerging therapeutic target for hypercholesterolemia and atherosclerosis. Acta Biochimica et Biophysica Sinica, 52(8), 914-915.

Yu, H., Rimbert, A., Palmer, A. E., Toyohara, T., Xia, Y., Xia, F., ... & Cowan, C. A. (2019). GPR146 deficiency protects against hypercholesterolemia and atherosclerosis. Cell, 179(6), 1276-1288.

Yu, H., Rimbert, A., Palmer, A., Toyohara, T., Xia, Y., Xia, F., ... & Cowan, C. (2019). Orphan Receptor GPR146 Deficiency Reduces Plasma Cholesterol Levels and Protects Against Atherosclerosis. Circulation, 140(Suppl_1), A12855-A12855.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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