Rabbit Anti-GPR171 Recombinant Antibody (EG1391) (CBMAB-EN1670-LY)

The product is antibody recognizes GPR171. The antibody EG1391 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all GPR171 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

EG1391

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GPR171.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

G protein-coupled receptor 171

Entrez Gene ID

29909

UniProt ID

O14626

Alternative Names

H963

Function

Orphan receptor.

Biological Process

G protein-coupled receptor signaling pathway Source: GO_Central
Negative regulation of myeloid cell differentiation Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-21
Helical: 22-42
Cytoplasmic: 43-48
Helical: 49-69
Extracellular: 70-89
Helical: 90-110
Cytoplasmic: 111-132
Helical: 133-153
Extracellular: 154-181
Helical: 182-202
Cytoplasmic: 203-224
Helical: 225-245
Extracellular: 246-268
Helical: 269-289
Cytoplasmic: 290-319

References

Fujiwara, Y., Torphy, R. J., Sun, Y., Miller, E. N., Ho, F., Borcherding, N., ... & Zhu, Y. (2021). The GPR171 pathway suppresses T cell activation and limits antitumor immunity. Nature communications, 12(1), 5857.

Davenport, A. P., Scully, C. C., de Graaf, C., Brown, A. J., & Maguire, J. J. (2020). Advances in therapeutic peptides targeting G protein-coupled receptors. Nature Reviews Drug Discovery, 19(6), 389-413.

Laschet, C., Dupuis, N., & Hanson, J. (2018). The G protein-coupled receptors deorphanization landscape. Biochemical Pharmacology, 153, 62-74.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Datasheet
SDS
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Second antibody and isotype control

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