Mouse Anti-GPR83 Recombinant Antibody (K07JP05) (CBMAB-G4669-LY)

This product is antibody recognizes GPR83. The antibody K07JP05 immunoassay techniques such as: FC.
See all GPR83 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

K07JP05

Antibody Isotype

IgG2a, κ

Application

Basic Information

Immunogen

DNA vaccine with full coding sequence of human GPCR cloned in expression vector

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.09% sodium azide

Concentration

0.5 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

G protein-coupled receptor 83

Entrez Gene ID

10888

UniProt ID

Q9NYM4

Alternative Names

GIR; GPR72

Function

Orphan receptor. Could be a neuropeptide Y receptor.

Biological Process

Response to glucocorticoid Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 18-71
Helical: 72-92
Cytoplasmic: 93-107
Helical: 108-129
Extracellular: 130-145
Helical: 146-167
Cytoplasmic: 168-186
Helical: 187-208
Extracellular: 209-238
Helical: 239-260
Cytoplasmic: 261-293
Helical: 294-315
Extracellular: 316-327
Helical: 328-348
Cytoplasmic: 349-423

References

Li, H. Z., Wang, Y. F., Hu, W. F., Liu, Y. L., Xu, Z. G., & Guo, Z. Y. (2023). Nanomolar range of FAM237B can activate receptor GPR83. bioRxiv, 2023-05.

Li, H. Z., Wang, Y. F., Shao, X. X., Liu, Y. L., Xu, Z. G., Wang, S. L., & Guo, Z. Y. (2023). FAM237A, rather than peptide PEN and proCCK56‐63, binds to and activates the orphan receptor GPR83. The FEBS Journal.

Mack, S. M., Gomes, I., Fakira, A. K., Duarte, M. L., Gupta, A., Fricker, L., & Devi, L. A. (2022). GPR83 engages endogenous peptides from two distinct precursors to elicit differential signaling. Molecular Pharmacology, 102(1), 29-38.

Zheng, X., Konkalmatt, P., Asico, L., Jose, P. A., & Armando, I. (2018). Salt Resistance and Renal Gpr83 Function. Hypertension, 72(Suppl_1), A093-A093.

Lueptow, L. M., Devi, L. A., & Fakira, A. K. (2018). Targeting the recently deorphanized receptor GPR83 for the treatment of immunological, neuroendocrine and neuropsychiatric disorders. Progress in molecular biology and translational science, 159, 1-25.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-GPR83 (N-terminus) Recombinant Antibody (CBFYH-3470)

Rabbit Anti-GPR83 Recombinant Antibody (EG1409)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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