Rabbit Anti-GPS1 Recombinant Antibody (EP15642-22) (CBMAB-1573-CN)

Name: Rabbit Anti-GPS1 Recombinant Antibody (EP15642-22)
SKU: CBMAB-1573-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EP15642-22

Application

WB, IHC-P, IF

Immunogen

Recombinant fragment within Human CSN1 aa. 50-200.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

59% PBS, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium azide

Concentration

1.811 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

G protein pathway suppressor 1

Introduction

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.

Entrez Gene ID

Human	2873
Mouse	209318
Rat	117039

UniProt ID

Human	Q13098
Mouse	Q99LD4
Rat	P97834

Alternative Names

CSN1; SGN1; COPS1

Function

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Biological Process

Inactivation of MAPK activity Source: ProtInc
JNK cascade Source: ProtInc
Protein deneddylation Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm

Horváth, A., Rona, G., Pagano, M., & Jordan, P. W. (2020). Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome. BMC Molecular and Cell Biology, 21(1), 1-10.

Kuwahara, T., Yamayoshi, S., Noda, T., & Kawaoka, Y. (2019). G Protein Pathway Suppressor 1 Promotes Influenza Virus Polymerase Activity by Activating the NF-κB Signaling Pathway. Mbio, 10(6), e02867-19.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-GPS1 Recombinant Antibody (CBWJC-3745) (CAT#: CBMAB-C5010WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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