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Mouse Anti-GREB1 Recombinant Antibody (GREB1Ab) (CBMAB-G4824-LY)

This product is antibody recognizes GREB1. The antibody GREB1Ab immunoassay techniques such as: IC, IHC, WB.
See all GREB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
GREB1Ab
Antibody Isotype
IgG1, κ
Application
IC, IHC, WB

Basic Information

Immunogen
Recombinant protein corresponding to human GREB1
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Growth Regulation By Estrogen In Breast Cancer 1
Introduction
This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
9687
UniProt ID
Q4ZG55
Alternative Names
Growth Regulation By Estrogen In Breast Cancer 1; Gene Regulated By Estrogen In Breast Cancer; Gene Regulated In Breast Cancer 1 Protein; KIAA0575;
Function
May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
Cellular Location
Membrane
Topology
Helical: 1868-1888

Yin, X., Wang, M., He, H., Ru, G., & Zhao, M. (2023). Uterine Tumor Resembling Ovarian Sex Cord Tumor With Aggressive Histologic Features Harboring a GREB1-NCOA2 Fusion: Case Report With a Brief Review. International Journal of Gynecological Pathology, 42(1), 54-62.

Kao, Y. C., & Lee, J. C. (2021). An update of molecular findings in uterine tumor resembling ovarian sex cord tumor and GREB1‐rearranged uterine sarcoma with variable sex‐cord differentiation. Genes, Chromosomes and Cancer, 60(3), 180-189.

Shin, E. M., Huynh, V. T., Neja, S. A., Liu, C. Y., Raju, A., Tan, K., ... & Tergaonkar, V. (2021). GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer. Science Advances, 7(12), eabe2470.

Matsumoto, S., Yamamichi, T., Shinzawa, K., Kasahara, Y., Nojima, S., Kodama, T., ... & Kikuchi, A. (2019). GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling. Nature communications, 10(1), 3882.

Lee, C. H., Kao, Y. C., Lee, W. R., Hsiao, Y. W., Lu, T. P., Chu, C. Y., ... & Lee, J. C. (2019). Clinicopathologic characterization of GREB1-rearranged uterine sarcomas with variable sex-cord differentiation. The American journal of surgical pathology, 43(7), 928-942.

Matalliotaki, C., Matalliotakis, M., Rahmioglu, N., Mavromatidis, G., Matalliotakis, I., Koumantakis, G., ... & Zervou, M. I. (2019). Role of FN1 and GREB1 gene polymorphisms in endometriosis. Molecular Medicine Reports, 20(1), 111-116.

Croce, S., Lesluyes, T., Delespaul, L., Bonhomme, B., Pérot, G., Velasco, V., ... & Chibon, F. (2019). GREB1‐CTNNB1 fusion transcript detected by RNA‐sequencing in a uterine tumor resembling ovarian sex cord tumor (UTROSCT): A novel CTNNB1 rearrangement. Genes, Chromosomes and Cancer, 58(3), 155-163.

Hodgkinson, K., Forrest, L. A., Vuong, N., Garson, K., Djordjevic, B., & Vanderhyden, B. C. (2018). GREB1 is an estrogen receptor-regulated tumour promoter that is frequently expressed in ovarian cancer. Oncogene, 37(44), 5873-5886.

Wu, Y., Zhang, Z., Cenciarini, M. E., Proietti, C. J., Amasino, M., Hong, T., ... & Xu, K. (2018). Tamoxifen resistance in breast cancer is regulated by the EZH2–ERα–GREB1 transcriptional axis. Cancer research, 78(3), 671-684.

Cheng, M., Michalski, S., & Kommagani, R. (2018). Role for growth regulation by estrogen in breast cancer 1 (GREB1) in hormone-dependent cancers. International journal of molecular sciences, 19(9), 2543.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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