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Rabbit Anti-GRM1 Recombinant Antibody (BA0130) (CBMAB-0359CQ)

This product is a rabbit antibody that recognizes GRM1. The antibody BA0130 can be used for immunoassay techniques such as: WB.
See all GRM1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0130
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Human Metabotropic Glutamate Receptor 1a aa 300-400
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
glutamate metabotropic receptor 1
Introduction
Glutamate receptors are divided into 2 distinct classes: ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The iGluRs consist of N-methyl-D-aspartate (NMDA) receptors and non-NMDA receptors. Non-NMDA receptors are further subdivided into 2 groups: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (e.g., GRIA1; 138248) and kainate receptors (e.g., GRIK1; 138245). This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
Entrez Gene ID
Human2911
Mouse14816
Rat24414
UniProt ID
HumanQ13255
MouseP97772
RatP23385
Alternative Names
MGLU1; GPRC1A; MGLUR1; SCAR13; PPP1R85
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890).

May function in the light response in the retina (By similarity).
Biological Process
Activation of MAPK activity Source: Ensembl
Activation of MAPKK activity Source: Ensembl
Cellular response to electrical stimulus Source: Ensembl
Chemical synaptic transmission Source: ProtInc
G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: UniProtKB
L-glutamate import across plasma membrane Source: Ensembl
Locomotory behavior Source: Ensembl
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: UniProtKB
Regulation of sensory perception of pain Source: Ensembl
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Sensory perception of pain Source: Ensembl
Cellular Location
Cell membrane
Involvement in disease
Spinocerebellar ataxia, autosomal recessive, 13 (SCAR13):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR13 is characterized by delayed psychomotor development beginning in infancy. Affected individuals show mild to profound mental retardation with poor or absent speech as well as gait and stance ataxia and hyperreflexia.
Spinocerebellar ataxia 44 (SCA44):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA44 is a slowly progressive, autosomal dominant form.
Topology
Extracellular: 19-592
Helical: 593-615
Cytoplasmic: 616-629
Helical: 630-650
Extracellular: 651-658
Helical: 659-680
Cytoplasmic: 681-703
Helical: 704-727
Extracellular: 728-750
Helical: 751-772
Cytoplasmic: 773-785
Helical: 786-807
Extracellular: 808-815
Helical: 816-840
Cytoplasmic: 841-1194
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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