Mouse Anti-GRM6 Recombinant Antibody (CBT2009) (V2LY-0625-LY720)

Name: Mouse Anti-GRM6 Recombinant Antibody (CBT2009)
SKU: V2LY-0625-LY720
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-GRM6 Recombinant Antibody (CBT2009) (V2LY-0625-LY720) in ELISA

Mouse Anti-GRM6 Recombinant Antibody (CBT2009) (V2LY-0625-LY720) in WB

Mouse Anti-GRM6 Recombinant Antibody (CBT2009) (V2LY-0625-LY720) in FC

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT2009

Application

Immunogen

Purified recombinant fragment of human GRM6 (AA: extra 480-585) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

glutamate receptor, metabotropic 6

Entrez Gene ID

2916

UniProt ID

O15303

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity).

Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision.

Biological Process

Chemical synaptic transmission Source: Ensembl
Detection of light stimulus involved in visual perception Source: UniProtKB
Detection of visible light Source: ProtInc
G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Locomotory behavior Source: Ensembl
Positive regulation of calcium ion import Source: UniProtKB
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Retina development in camera-type eye Source: Ensembl

Cellular Location

Endoplasmic reticulum membrane; Golgi apparatus membrane; Cell membrane; Dendrite. Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.

Involvement in disease

Night blindness, congenital stationary, 1B (CSNB1B):
A non-progressive retinal disorder characterized by impaired night vision. Congenital stationary night blindness type 1B is an autosomal recessive form associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced on response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background.

Topology

Extracellular: 25-585
Helical: 586-608
Cytoplasmic: 609-622
Helical: 623-643
Extracellular: 644-654
Helical: 655-673
Cytoplasmic: 674-697
Helical: 698-718
Extracellular: 719-748
Helical: 749-770
Cytoplasmic: 771-783
Helical: 784-806
Extracellular: 807-819
Helical: 820-845
Cytoplasmic: 846-877

Hack, Y. L., Crabtree, E. E., Avila, F., Sutton, R. B., Grahn, R., Oh, A., ... & Bellone, R. R. (2021). Whole‐genome sequencing identifies missense mutation in GRM6 as the likely cause of congenital stationary night blindness in a Tennessee Walking Horse. Equine veterinary journal, 53(2), 316-323.

Tourville, A., Michiels, C., Condroyer, C., Meunier, A., Cordonnier, M., Sahel, J. A., ... & Zeitz, C. (2019). Identification of a novel GRM6 mutation in a previously described consanguineous family with complete congenital stationary night blindness. Ophthalmic Genetics, 40(2), 182-184.

Wang, R. Y., Chen, H. J., Huang, C. L., Wang, J. Y., Lee, T. E., Lee, H. Y., & Hung, C. C. (2018). Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population. PloS one, 13(7), e0201408.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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