Mouse Anti-GSTA2 Recombinant Antibody (3D4) (CBMAB-G5455-LY)

Name: Mouse Anti-GSTA2 Recombinant Antibody (3D4)
SKU: CBMAB-G5455-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

3D4

Antibody Isotype

IgG1, κ

Application

ELISA, IF, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

glutathione S-transferase alpha 2

Introduction

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]

Entrez Gene ID

2939

UniProt ID

P09210

Alternative Names

Glutathione S-Transferase Alpha 2; Glutathione S-Transferase A2; GST Class-Alpha Member 2; GST HA Subunit 2; EC 2.5.1.18; GST-Gamma; GSTA2-2; GST2; GTH2;

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Biological Process

Epithelial cell differentiation Source: UniProtKB
Glutathione metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: GO_Central

Cellular Location

Cytoplasm

More Infomation

References

Choi, Y. J., Shin, M. J., Youn, G. S., Park, J. H., Yeo, H. J., Yeo, E. J., ... & Choi, S. Y. (2023). Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress. International Journal of Molecular Sciences, 24(3), 2767.

Garige, M., & Walters, E. (2021). Characterization of glutathione S-transferase enzymes in Dictyostelium discoideum suggests a functional role for the GSTA2 isozyme in cell proliferation and development. Plos one, 16(4), e0250704.

Liu, J., Liu, H., Zhao, Z., Wang, J., Guo, D., & Liu, Y. (2020). Regulation of Actg1 and Gsta2 is possible mechanism by which capsaicin alleviates apoptosis in cell model of 6-OHDA-induced Parkinson's disease. Bioscience Reports, 40(6).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-GSTA2 Recombinant Antibody (CBLG1-2000)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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