Mouse Anti-GTF2H2 Recombinant Antibody (GTF2F6A10) (CBMAB-G5708-LY)

Name: Mouse Anti-GTF2H2 Recombinant Antibody (GTF2F6A10)
SKU: CBMAB-G5708-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

GTF2F6A10

Application

Dot Blot

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

1% BSA

Concentration

0.1 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

GTF2H2

Entrez Gene ID

2966

UniProt ID

Q13888

Alternative Names

General Transcription Factor IIH Subunit 2; General Transcription Factor IIH; Polypeptide 2; 44kDa; TFIIH Basal Transcription Factor Complex P44 Subunit; General Transcription Factor IIH Polypeptide 2; Basic Transcription Factor 2 44 KDa Subunit; BTF2 P44; BTF2P44;

Function

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.

Biological Process

G protein-coupled receptor internalization Source: UniProtKB
Nucleotide-excision repair Source: GO_Central
Positive regulation of DNA helicase activity Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to UV Source: ProtInc
Transcription by RNA polymerase II Source: UniProtKB
Transcription initiation from RNA polymerase II promoter Source: GO_Central

Cellular Location

Nucleus

Li, Z., Li, Y., Ouyang, Q., Li, X., & Huang, J. (2022). Exosome-derived GTF2H2 from Huh7 cells can inhibit endothelial cell viability, migration, tube formation, and permeability. Tissue and Cell, 79, 101922.

Li, X., Liu, L., Song, X., Wang, K., Niu, L., Xie, L., & Song, X. (2021). TEP linc-GTF2H2-1, RP3-466P17. 2, and lnc-ST8SIA4-12 as novel biomarkers for lung cancer diagnosis and progression prediction. Journal of Cancer Research and Clinical Oncology, 147, 1609-1622.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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