Mouse Anti-GYG2 Recombinant Antibody (3D10) (CBMAB-G5823-LY)

Name: Mouse Anti-GYG2 Recombinant Antibody (3D10)
SKU: CBMAB-G5823-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3D10

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa392-502 from human GYG2 (NP_003909) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Glycogenin 2

Introduction

This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]

Entrez Gene ID

8908

UniProt ID

O15488

Alternative Names

Glycogenin 2; Glycogenin Glucosyltransferase; EC 2.4.1.186; GN-2; GN2; Glycogenin-2;

Function

Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.

Biological Process

Glycogen biosynthetic process Source: UniProtKB

Cellular Location

Cytosol; Cytoplasm

PTM

Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-228.

De Filippi, P., Errichiello, E., Toscano, A., Mongini, T., Moggio, M., Ravaglia, S., ... & Danesino, C. (2023). Distribution of Exonic Variants in Glycogen Synthesis and Catabolism Genes in Late Onset Pompe Disease (LOPD). Current Issues in Molecular Biology, 45(4), 2847-2860.

Visuttijai, K., Hedberg-Oldfors, C., Thomsen, C., Glamuzina, E., Kornblum, C., Tasca, G., ... & Oldfors, A. (2020). Glycogenin is dispensable for glycogen synthesis in human muscle, and glycogenin deficiency causes polyglucosan storage. The Journal of Clinical Endocrinology & Metabolism, 105(2), 557-566.

Pursell, N., Gierut, J., Zhou, W., Dills, M., Diwanji, R., Gjorgjieva, M., ... & Lai, C. (2018). Inhibition of glycogen synthase II with RNAi prevents liver injury in mouse models of glycogen storage diseases. Molecular Therapy, 26(7), 1771-1782.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

GYG2 Matched Antibody Pair (521) (CAT#: APMAB-521LY)

GYG2 Matched Antibody Pair (522) (CAT#: APMAB-522LY)

Related Products

GYG2 Matched Antibody Pair (522) (CAT#: APMAB-522LY)

Mouse Anti-GYG2 Recombinant Antibody (CBLG1-2157) (CAT#: CBMAB-G5824-LY)

GYG2 Matched Antibody Pair (521) (CAT#: APMAB-521LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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