Rabbit Anti-HAMP Recombinant Antibody (
4C5) (V2LY-0725-LY745)

Hepcidin Antimicrobial Peptide

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342).

Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).

Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317).

Acute-phase response Source: Ensembl
Aging Source: Ensembl
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular iron ion homeostasis Source: BHF-UCL
Cellular response to bile acid Source: Ensembl
Cellular response to interleukin-6 Source: Ensembl
Cellular response to lipopolysaccharide Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Cellular response to X-ray Source: Ensembl
Defense response to bacterium Source: GO_Central
Defense response to fungus Source: UniProtKB
Defense response to Gram-negative bacterium Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
Immune response Source: UniProtKB
Killing of cells of other organism Source: UniProtKB
Liver regeneration Source: Ensembl
Multicellular organismal iron ion homeostasis Source: BHF-UCL
Myeloid cell homeostasis Source: Ensembl
Negative regulation of bone resorption Source: Ensembl
Negative regulation of inflammatory response Source: Ensembl
Negative regulation of intestinal absorption Source: BHF-UCL
Negative regulation of ion transmembrane transporter activity Source: BHF-UCL
Negative regulation of iron export across plasma membrane Source: BHF-UCL
Negative regulation of iron ion transmembrane transport Source: GO_Central
Negative regulation of iron ion transmembrane transporter activity Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
Positive regulation of cellular protein catabolic process Source: Ensembl
Positive regulation of macrophage activation Source: Ensembl
Positive regulation of protein polyubiquitination Source: BHF-UCL
Positive regulation of receptor catabolic process Source: BHF-UCL
Positive regulation of receptor internalization Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Receptor signaling pathway via JAK-STAT Source: Ensembl
Response to erythropoietin Source: Ensembl
Response to ethanol Source: Ensembl
Response to iron ion Source: BHF-UCL
Response to iron ion starvation Source: Ensembl
Response to vitamin A Source: Ensembl
Response to zinc ion Source: Ensembl

Secreted

Hemochromatosis 2B (HFE2B):
A juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy.