Mouse Anti-HLA A*0201 MHC Class I Recombinant Antibody (A192) (CBMAB-AP3085LY)

HLA A*0201 MHC Class I

08-9467-2

Antibacterial humoral response Source: UniProtKB
Antigen processing and presentation of endogenous peptide antigen via MHC class I Source: UniProtKB
Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: UniProtKB
Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent Source: UniProtKB
Antigen processing and presentation of exogenous peptide antigen via MHC class I Source: UniProtKB
CD8-positive, alpha-beta T cell activation Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
Detection of bacterium Source: UniProtKB
Immune response Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Positive regulation of CD8-positive, alpha-beta T cell activation Source: BHF-UCL
Positive regulation of CD8-positive, alpha-beta T cell proliferation Source: UniProtKB
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of memory T cell activation Source: UniProtKB
Positive regulation of T cell cytokine production Source: BHF-UCL
Positive regulation of T cell mediated cytotoxicity Source: UniProtKB
Protection from natural killer cell mediated cytotoxicity Source: UniProtKB
T cell mediated cytotoxicity Source: UniProtKB
T cell mediated cytotoxicity directed against tumor cell target Source: UniProtKB
T cell receptor signaling pathway Source: UniProtKB

Endoplasmic reticulum membrane; Cell membrane

Alleles A*02:01 and A*24:02 are associated with increased susceptibility to diabetes mellitus, insulin-dependent (IDDM) (PubMed:22245737, PubMed:18802479, PubMed:16731854, PubMed:22522618). In a glucose-dependent way, allele A*02:01 may aberrantly present the signal peptide of preproinsulin (ALWGPDPAAA) on the surface of pancreatic beta cells to autoreactive CD8-positive T cells, potentially driving T-cell mediated cytotoxicity in pancreatic islets (PubMed:22245737, PubMed:18802479). Allele A*24:02 may present the signal peptide of preproinsulin (LWMRLLPLL) and contribute to acute pancreatic beta-cell destruction and early onset of IDDM (PubMed:16731854, PubMed:22522618).

Extracellular: 25-308
Helical: 309-332
Cytoplasmic: 333-365

(Microbial infection) Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system.
N-linked glycosylation at Asn-110.