Mouse Anti-IL12RB1 Recombinant Antibody (TOS) (CBMAB-C11673-LY)

Name: Mouse Anti-IL12RB1 Recombinant Antibody (TOS)
SKU: CBMAB-C11673-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

TOS

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interleukin 12 Receptor Subunit Beta 1

Introduction

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Entrez Gene ID

3594

UniProt ID

P42701

Alternative Names

Interleukin 12 Receptor Subunit Beta 1

Function

Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

Biological Process

Cellular response to interferon-gamma Source: BHF-UCL
Cytokine-mediated signaling pathway Source: GO_Central
Interleukin-12-mediated signaling pathway Source: GOC
Interleukin-23-mediated signaling pathway Source: GOC
Positive regulation of activated T cell proliferation Source: BHF-UCL
Positive regulation of defense response to virus by host Source: BHF-UCL
Positive regulation of interferon-gamma production Source: BHF-UCL
Positive regulation of memory T cell differentiation Source: BHF-UCL
Positive regulation of natural killer cell proliferation Source: ComplexPortal
Positive regulation of NK T cell proliferation Source: ComplexPortal
Positive regulation of receptor signaling pathway via JAK-STAT Source: ComplexPortal
Positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
Positive regulation of T cell proliferation Source: ComplexPortal
Positive regulation of T-helper 17 cell lineage commitment Source: BHF-UCL
Positive regulation of T-helper 17 type immune response Source: BHF-UCL
Positive regulation of T-helper 1 type immune response Source: BHF-UCL
Signal transduction Source: BHF-UCL

Cellular Location

Membrane

Involvement in disease

Immunodeficiency 30 (IMD30):
A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD30 has low penetrance, and affected individuals have relatively mild disease and good prognosis. BCG disease and salmonellosis are the most frequent infections in IMD30 patients.

Topology

Extracellular: 24-545
Helical: 546-570
Cytoplasmic: 571-662

Abdelmajeed, O., Ali, M. M. D., Erwa, N. H., Mustafa, A., Ahmed, Y. A., Ahmed, R. H. A., ... & Algam, S. (2023). Autosomal recessive IL12RB1 mutation: A case report of a Sudanese child and his father. Frontiers in Immunology, 14, 1135824.

Wang, X., Jia, L., Liu, Y., Wang, J., Qiu, C., Li, T., ... & Wan, Y. (2022). Immune Correlates of Disseminated BCG Infection in IL12RB1-Deficient Mice. Vaccines, 10(7), 1147.

Mejia, O. R., Claeys, T. A., Williams, A., Zafar, A., & Robinson, R. T. (2022). IL12RB1 allele bias in human TH cells is regulated by functional SNPs in its 3′ UTR. Cytokine, 158, 155993.

Sharifinejad, N., Mahdaviani, S. A., Jamee, M., Daneshmandi, Z., Moniri, A., Marjani, M., ... & Velayati, A. A. (2021). Leukocytoclastic vasculitis in patients with IL12B or IL12RB1 deficiency: case report and review of the literature. Pediatric Rheumatology, 19(1), 1-8.

Liu, M., Lu, B., Zeng, P., Huang, B., Xu, Y., Liang, H., ... & Zhang, Y. (2020). Compound Heterozygous Mutations of IL12RB1 in a Patient with Selective Defects in Th17 Differentiation. Journal of Clinical Immunology, 40, 647-652.

Zhou, X., Jia, W., Ni, Z., Wang, A., Liu, Z., Hou, M., ... & Zhang, X. (2019). Three novel compound heterozygous IL12RB1 mutations in Chinese patients with Mendelian susceptibility to mycobacterial disease. Plos one, 14(4), e0215648.

Reeme, A. E., Claeys, T. A., Aggarwal, P., Turner, A. J., Routes, J. M., Broeckel, U., & Robinson, R. T. (2019). Human IL12RB1 expression is allele-biased and produces a novel IL12 response regulator. Genes & Immunity, 20(3), 181-197.

Al-Kzayer, L. A. F. Y., Yassin, A. K., Salih, K. H., Shigemura, T., Sano, K., Al-Simaani, R. B. Y., ... & Okuno, Y. (2019). A Syrian refugee in Iraq diagnosed as a case of IL12RB1 deficiency in Japan using dried blood spots. Frontiers in immunology, 10, 58.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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