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Mouse Anti-KCNQ4 Recombinant Antibody (10F743) (CBMAB-K0609-LY)

This product is antibody recognizes KCNQ4. The antibody 10F743 immunoassay techniques such as: ICC, IP, WB.
See all KCNQ4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
10F743
Antibody Isotype
IgG1
Application
ICC, IP, WB

Basic Information

Immunogen
Fusion protein amino acid 2-77 of human KCNQ4 (Kv7.4, KvLQT4)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.09% sodium azide
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
potassium voltage-gated channel subfamily Q member 4
Introduction
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human9132
Mouse60613
Rat298496
UniProt ID
HumanP56696
MouseQ9JK97
RatQ9JK96
Alternative Names
Potassium Voltage-Gated Channel Subfamily Q Member 4; Potassium Channel; Voltage Gated KQT-Like Subfamily Q; Member 4; Potassium Voltage-Gated Channel; KQT-Like Subfamily; Member 4; Potassium Channel Subunit Alpha KvLQT4; Potassium Voltage-Gated Channel Subfamily KQT Member 4; Voltage-Gated Potassium Channel Subunit Kv7.4;
Function
Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
Biological Process
Inner ear morphogenesisIEA:Ensembl
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Sensory perception of soundManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Basal cell membrane. Situated at the basal membrane of cochlear outer hair cells.
Involvement in disease
Deafness, autosomal dominant, 2A (DFNA2A):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Cytoplasmic: 1-97
Helical: 98-118
Extracellular: 119-131
Helical: 132-152
Cytoplasmic: 153-172
Helical: 173-193
Extracellular: 194-201
Helical: 202-224
Cytoplasmic: 225-237
Helical: 238-258
Extracellular: 259-270
Pore-forming: 271-292
Extracellular: 293-296
Helical: 297-317
Cytoplasmic: 318-695

Zhang, Y., Dong, X., Guo, X., Li, C., Fan, Y., Liu, P., ... & Gao, P. (2023). LncRNA-BC069792 suppresses tumor progression by targeting KCNQ4 in breast cancer. Molecular cancer, 22(1), 1-19.

Oh, K. S., Roh, J. W., Joo, S. Y., Ryu, K., Kim, J. A., Kim, S. J., ... & Gee, H. Y. (2023). Overlooked KCNQ4 variants augment the risk of hearing loss. Experimental & Molecular Medicine, 55(4), 844-859.

Homma, K. (2022). The Pathological Mechanisms of Hearing Loss Caused by KCNQ1 and KCNQ4 Variants. Biomedicines, 10(9), 2254.

Zheng, H., Yan, X., Li, G., Lin, H., Deng, S., Zhuang, W., ... & Yan, Z. (2022). Proactive functional classification of all possible missense single-nucleotide variants in KCNQ4. Genome Research, 32(8), 1573-1584.

Thorpe, R. K., Walls, W. D., Corrigan, R., Schaefer, A., Wang, K., Huygen, P., ... & Smith, R. J. (2022). AudioGene: refining the natural history of KCNQ4, GSDME, WFS1, and COCH-associated hearing loss. Human genetics, 141(3-4), 877-887.

Rim, J. H., Choi, J. Y., Jung, J., & Gee, H. Y. (2021). Activation of KCNQ4 as a therapeutic strategy to treat hearing loss. International journal of molecular sciences, 22(5), 2510.

Li, T., Wu, K., Yue, Z., Wang, Y., Zhang, F., & Shen, H. (2021). Structural basis for the modulation of human KCNQ4 by small-molecule drugs. Molecular Cell, 81(1), 25-37.

Lee, S. Y., Choi, H. B., Park, M., Choi, I. S., An, J., Kim, A., ... & Choi, B. Y. (2021). Novel KCNQ4 variants in different functional domains confer genotype-and mechanism-based therapeutics in patients with nonsyndromic hearing loss. Experimental & Molecular Medicine, 53(7), 1192-1204.

Jung, J., Lin, H., Koh, Y. I., Ryu, K., Lee, J. S., Rim, J. H., ... & Gee, H. Y. (2019). Rare KCNQ4 variants found in public databases underlie impaired channel activity that may contribute to hearing impairment. Experimental & molecular medicine, 51(8), 1-12.

Shin, D. H., Jung, J., Koh, Y. I., Rim, J. H., Lee, J. S., Choi, H. J., ... & Gee, H. Y. (2019). A recurrent mutation in KCNQ4 in Korean families with nonsyndromic hearing loss and rescue of the channel activity by KCNQ activators. Human mutation, 40(3), 335-346.

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For research use only. Not intended for any clinical use.

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