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Rabbit Anti-KCNQ5 Recombinant Antibody (EG1772) (CBMAB-EN2111-LY)

The product is antibody recognizes KCNQ5. The antibody EG1772 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all KCNQ5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG1772
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human KCNQ5.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
potassium voltage-gated channel subfamily Q member 5
Introduction
This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human56479
Mouse226922
UniProt ID
HumanQ9NR82
MouseQ9JK45
Alternative Names
Kv7.5; MRD46
Function
Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1.
Biological Process
Potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Cellular Location
Cell membrane
Involvement in disease
Mental retardation, autosomal dominant 46 (MRD46):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD46 patients manifest developmental delay and mild to moderate intellectual disability.
Topology
Cytoplasmic: 1-125
Helical: 126-146
Extracellular: 147-156
Helical: 157-177
Cytoplasmic: 178-200
Helical: 201-221
Extracellular: 222-229
Helical: 230-252
Cytoplasmic: 253-266
Helical: 267-287
Extracellular: 288-298
Pore-forming: 299-319
Extracellular: 320-325
Helical: 326-346
Cytoplasmic: 347-932

Krüger, J., Schubert, J., Kegele, J., Labalme, A., Mao, M., Heighway, J., ... & Lerche, H. (2022). Loss-of-function variants in the KCNQ5 gene are implicated in genetic generalized epilepsies. EBioMedicine, 84.

Soh, H., Springer, K., Doci, K., Balsbaugh, J. L., & Tzingounis, A. V. (2022). KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3. Proceedings of the National Academy of Sciences, 119(13), e2117640119.

Wei, A. D., Wakenight, P., Zwingman, T. A., Bard, A. M., Sahai, N., Willemsen, M. H., ... & Kalume, F. K. (2022). Human KCNQ5 de novo mutations underlie epilepsy and intellectual disability. Journal of neurophysiology, 128(1), 40-61.

Clark, R., Pozarickij, A., Hysi, P. G., Ohno-Matsui, K., Williams, C., Guggenheim, J. A., & UK Biobank Eye and Vision Consortium. (2022). Education interacts with genetic variants near GJD2, RBFOX1, LAMA2, KCNQ5 and LRRC4C to confer susceptibility to myopia. PLoS Genetics, 18(11), e1010478.

Nappi, M., Barrese, V., Carotenuto, L., Lesca, G., Labalme, A., Ville, D., ... & Taglialatela, M. (2022). Gain of function due to increased opening probability by two KCNQ5 pore variants causing developmental and epileptic encephalopathy. Proceedings of the National Academy of Sciences, 119(15), e2116887119.

Redford, K. E., Rognant, S., Jepps, T. A., & Abbott, G. W. (2021). KCNQ5 potassium channel activation underlies vasodilation by tea. Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology, 55(Suppl 3), 46.

Cao, Y., Zhao, G., Yuan, M., Liu, X., Ma, Y., Cao, Y., ... & Fei, S. (2021). KCNQ5 and C9orf50 methylation in stool DNA for early detection of colorectal cancer. Frontiers in Oncology, 10, 621295.

Manville, R. W., van der Horst, J., Redford, K. E., Katz, B. B., Jepps, T. A., & Abbott, G. W. (2019). KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines. Proceedings of the National Academy of Sciences, 116(42), 21236-21245.

Wang, L., Qiao, G. H., Hu, H. N., Gao, Z. B., & Nan, F. J. (2018). Discovery of novel retigabine derivatives as potent KCNQ4 and KCNQ5 channel agonists with improved specificity. ACS Medicinal Chemistry Letters, 10(1), 27-33.

Manville, R. W., & Abbott, G. W. (2018). Gabapentin is a potent activator of KCNQ3 and KCNQ5 potassium channels. Molecular pharmacology, 94(4), 1155-1163.

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For research use only. Not intended for any clinical use.

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