Mouse Anti-KITLG Recombinant Antibody (CBXS-3583) (CBMAB-S0873-CQ)

Name: Mouse Anti-KITLG Recombinant Antibody (CBXS-3583)
SKU: CBMAB-S0873-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-3583

Application

ELISA

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

KIT Ligand

Introduction

This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

4254

UniProt ID

P21583

Alternative Names

KIT Ligand; Mast Cell Growth Factor; Stem Cell Factor; Familial Progressive Hyperpigmentation 2; Steel Factor; C-Kit Ligand; MGF; SCF; DFNA69;

Function

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Biological Process

Cell adhesionIEA:UniProtKB-KW
Ectopic germ cell programmed cell deathManual Assertion Based On ExperimentIMP:MGI
Embryonic hemopoiesisISO:MGI
Extrinsic apoptotic signaling pathway in absence of ligandManual Assertion Based On ExperimentIDA:MGI
Germ cell developmentManual Assertion Based On ExperimentTAS:MGI
Male gonad developmentIEA:Ensembl
Negative regulation of apoptotic processManual Assertion Based On ExperimentIGI:MGI
Negative regulation of mast cell apoptotic processManual Assertion Based On ExperimentIDA:MGI
Neural crest cell migrationManual Assertion Based On ExperimentIDA:MGI
Ovarian follicle developmentISO:MGI
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of hematopoietic stem cell proliferationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of leukocyte migrationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIGI:MGI
Positive regulation of mast cell proliferationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of melanocyte differentiationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of myeloid leukocyte differentiationManual Assertion Based On ExperimentIGI:MGI
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of Ras protein signal transductionManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Isoform 1: Cell membrane
Isoform 2: Cytoplasm; Cytoplasm, cytoskeleton; Cell projection, filopodium
Soluble KIT ligand: Secreted

Topology

Extracellular: 26-214
Helical: 215-237
Cytoplasmic: 238-273

PTM

A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.

Huang, J. C., Chen, S. C., Chang, W. A., Hung, W. W., Wu, P. H., Wu, L. Y., ... & Tsai, Y. C. (2022). KITLG Promotes Glomerular Endothelial Cell Injury in Diabetic Nephropathy by an Autocrine Effect. International Journal of Molecular Sciences, 23(19), 11723.

Ling, J., Zhang, L., Chang, A., Huang, Y., Ren, J., Zhao, H., & Zhuo, X. (2022). Overexpression of KITLG predicts unfavorable clinical outcomes and promotes lymph node metastasis via the JAK/STAT pathway in nasopharyngeal carcinoma. Laboratory Investigation, 102(11), 1257-1267.

Wang, J., Li, W., Zhou, N., Liu, J., Zhang, S., Li, X., ... & Li, M. (2021). Identification of a novel mutation in the KITLG gene in a Chinese family with familial progressive hyper-and hypopigmentation. BMC Medical Genomics, 14(1), 1-7.

Young, I. C., Wu, B., Andricovich, J., Chuang, S. T., Li, R., Tzatsos, A., ... & Wu, M. Y. (2021). Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling. Cell reports, 37(8).

Kato, M., Yagami, A., Tsukamoto, T., Shinkai, Y., Kato, T., & Kurahashi, H. (2020). Novel mutation in the KITLG gene in familial progressive hyperpigmentation with or without hypopigmentation. The Journal of Dermatology, 47(6), 669-672.

Yang, Z., Liu, S., Wang, Y., Chen, Y., Zhang, P., Liu, Y., ... & Xiong, K. (2020). High expression of KITLG is a new hallmark activating the MAPK pathway in type A and AB thymoma. Thoracic Cancer, 11(7), 1944-1954.

Bannasch, D. L., Affolter, V. K., York, D., Rebhun, R. B., Grahn, R. A., Weich, K. M., & Kallenberg, A. (2020). Pigment intensity in dogs is associated with a copy number variant upstream of KITLG. Genes, 11(1), 75.

Qin, J. X., Cai, Z. L., Yang, Y. F., Xing, J. C., & Zhuang, X. (2019). Association between KITLG gene polymorphisms and testicular germ cell tumors: a systematic review and meta-analysis. Current Medical Science, 39(5), 702-706.

Wrigglesworth, J., Ancelin, M. L., Ritchie, K., & Ryan, J. (2019). Association between DNA methylation of the KITLG gene and cortisol levels under stress: a replication study. Stress, 22(1), 162-168.

Yang, Z., Shi, H., Ma, P., Zhao, S., Kong, Q., Bian, T., ... & Su, B. (2018). Darwinian positive selection on the pleiotropic effects of KITLG explain skin pigmentation and winter temperature adaptation in Eurasians. Molecular Biology and Evolution, 35(9), 2272-2283.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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