Mouse Anti-KRT17 Recombinant Antibody (CBT21) (V2LY-0625-LY3862)

Name: Mouse Anti-KRT17 Recombinant Antibody (CBT21)
SKU: V2LY-0625-LY3862
Rating: 5 (1 reviews)

See all KRT17 antibodies

Compare Online Inquiry

Tested Data

Mouse Anti-KRT17 Recombinant Antibody (CBT21) (V2LY-0625-LY3862) in IF

Mouse Anti-KRT17 Recombinant Antibody (CBT21) (V2LY-0625-LY3862) in IHC

Mouse Anti-KRT17 Recombinant Antibody (CBT21) (V2LY-0625-LY3862) in WB

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT21

Application

WB, IHC-P, IF, ICC, IP

Immunogen

Synthetic Peptide of CK17

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IF	1:200
IHC	1:50-1:300
IP	1:200
WB	1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, Glycerol, BSA

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

keratin 17

Entrez Gene ID

3872

UniProt ID

Q04695

Function

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity).
Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity).
Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity).
Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity).
May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Biological Process

Hair follicle morphogenesisISS:UniProtKB
Intermediate filament organizationIEA:Ensembl
KeratinizationIEA:Ensembl
Positive regulation of cell growthIEA:Ensembl
Positive regulation of hair follicle developmentIEA:Ensembl
Positive regulation of translationIEA:Ensembl

Cellular Location

Cytoplasm

Involvement in disease

Pachyonychia congenita 2 (PC2):
An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth.
Steatocystoma multiplex (SM):
Disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs.
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

PTM

Phosphorylation at Ser-44 ^oCcurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.

Zhang, H., Zhang, Y., Feng, Z., Lu, L., Li, Y., Liu, Y., & Chen, Y. (2022). Analysis of the Expression and Role of Keratin 17 in Human Tumors. Frontiers in Genetics, 13, 801698.

Li, M., Rao, X., Cui, Y., Zhang, L., Li, X., Wang, B., ... & Zhuo, W. (2022). The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer. Oncogene, 41(6), 770-781.

Li, C., Teng, Y., Wu, J., Yan, F., Deng, R., Zhu, Y., & Li, X. (2021). A pan-cancer analysis of the oncogenic role of Keratin 17 (KRT17) in human tumors. Translational cancer research, 10(10), 4489.

Ji, R., Ji, Y., Ma, L., Ge, S., Chen, J., Wu, S., ... & Liu, Z. (2021). Keratin 17 upregulation promotes cell metastasis and angiogenesis in colon adenocarcinoma. Bioengineered, 12(2), 12598-12611.

Jacob, J. T., Nair, R. R., Poll, B. G., Pineda, C. M., Hobbs, R. P., Matunis, M. J., & Coulombe, P. A. (2020). Keratin 17 regulates nuclear morphology and chromatin organization. Journal of cell science, 133(20), jcs254094.

Liu, Z., Yu, S., Ye, S., Shen, Z., Gao, L., Han, Z., ... & Kang, M. (2020). Keratin 17 activates AKT signalling and induces epithelial-mesenchymal transition in oesophageal squamous cell carcinoma. Journal of proteomics, 211, 103557.

Yang, L., Zhang, S., & Wang, G. (2019). Keratin 17 in disease pathogenesis: from cancer to dermatoses. The Journal of pathology, 247(2), 158-165.

Liu, J., Liu, L., Cao, L., & Wen, Q. (2018). Keratin 17 promotes lung adenocarcinoma progression by enhancing cell proliferation and invasion. Medical science monitor: international medical journal of experimental and clinical research, 24, 4782.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-KRT17 Recombinant Antibody (CBT21)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-KRT17 Recombinant Antibody (CBWJC-4002) (CAT#: CBMAB-C5318WJ)

Mouse Anti-KRT17 Recombinant Antibody (4A32) (CAT#: CBMAB-C6585-LY)

Mouse Anti-KRT17 Recombinant Antibody (A798) (CAT#: CBMAB-AP11221LY)

Mouse Anti-KRT17 Recombinant Antibody (CBCNC-629) (CAT#: CBMAB-C3804-CN)

Mouse Anti-KRT17 Recombinant Antibody (3H2058) (CAT#: CBMAB-K1662-LY)

Mouse Anti-KRT17 Recombinant Antibody (CAP920) (CAT#: CBMAB-AP2863LY)

Mouse Anti-KRT17 Recombinant Antibody (CBWJC-2279) (CAT#: CBMAB-C3146WJ)

Mouse Anti-KRT17 Recombinant Antibody (CBCNC-630) (CAT#: CBMAB-C3805-CN)

Mouse Anti-KRT17 Recombinant Antibody (CBT3106) (CAT#: V2LY-0625-LY2305)

Mouse Anti-KRT17 Recombinant Antibody (CAP918) (CAT#: CBMAB-AP2854LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry