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Rabbit Anti-LMTK2 Recombinant Antibody (CBLY1-167) (CBMAB-K2101-LY)

This product is antibody recognizes LMTK2. The antibody CBLY1-167 immunoassay techniques such as: WB, IHC-P.
See all LMTK2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBLY1-167
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
lemur tyrosine kinase 2
Introduction
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.
Entrez Gene ID
22853
UniProt ID
Q8IWU2
Alternative Names
BREK; KPI2; LMR2; cprk; KPI-2; hBREK; AATYK2; PPP1R100
Function
Phosphorylates PPP1C, phosphorylase b and CFTR.
Biological Process
AxonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-threonine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Receptor recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Transferrin transportManual Assertion Based On ExperimentIMP:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Cytoplasmic: 1-10
Helical: 11-31
Lumenal: 32-42
Helical: 43-63
Cytoplasmic: 64-1503
PTM
Autophosphorylated. Phosphorylated (By similarity).

Zhang, L., & Shu, F. (2023). LMTK2 inhibits Aβ25-35-elicited ferroptosis, oxidative stress and apoptotic damage in PC12 cells through activating Nrf2/ARE signalling pathway. Folia Neuropathologica, 61(1).

Vezelis, A., Simiene, J., Dabkeviciene, D., Kincius, M., Ulys, A., Suziedelis, K., ... & Jankevicius, F. (2021). LMTK2 as potential biomarker for stratification between clinically insignificant and clinically significant prostate cancer. Journal of oncology, 2021.

Rui, Q., Cao, S., Wang, X., Duan, X., Iao, X., Dong, W., ... & Xue, Q. (2021). LMTK2 regulates inflammation in lipopolysaccharide‑stimulated BV2 cells. Experimental and Therapeutic Medicine, 21(3), 1-1.

Cruz, D. F., Mitash, N., Mu, F., Farinha, C. M., & Swiatecka-Urban, A. (2021). Differential Gene Expression Analysis Reveals Global LMTK2 Regulatory Network and Its Role in TGF-β1 Signaling. Frontiers in Oncology, 11, 596861.

Bencze, J., Szarka, M., Bencs, V., Szabó, R. N., Módis, L. V., Aarsland, D., & Hortobágyi, T. (2020). Lemur tyrosine kinase 2 (LMTK2) level inversely correlates with phospho-tau in neuropathological stages of Alzheimer’s disease. Brain Sciences, 10(2), 68.

Bencze, J., Szarka, M., Bencs, V., Szabó, R. N., Smajda, M., Aarsland, D., & Hortobágyi, T. (2019). Neuropathological characterization of Lemur tyrosine kinase 2 (LMTK2) in Alzheimer’s disease and neocortical Lewy body disease. Scientific Reports, 9(1), 17222.

Mórotz, G. M., Glennon, E. B., Gomez-Suaga, P., Lau, D. H., Robinson, E. D., Sedlák, É., ... & Miller, C. C. (2019). LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains. Acta Neuropathologica Communications, 7, 1-16.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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