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Mouse Anti-LPCAT3 Recombinant Antibody (A919) (CBMAB-AP4338LY)


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Summary

Host Animal
Mouse
Specificity
Human, Pig
Clone
A919
Antibody Isotype
IgG
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
Met122~Arg233
Specificity
Human, Pig
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
Human10162
Pig100627653
UniProt ID
HumanQ6P1A2
PigA0A481BA38
Alternative Names
MBOAT5, C3F, OACT5, Nessy, LPSAT, Membrane Bound O-AcylTransferase Domain Containing 5, Lysophospholipid Acyltransferase 5, Lysophosphatidylserine acyltransferase
Function
MAG531Hu21
Biological Process
Chylomicron assemblyISS:UniProtKB
Endoplasmic reticulum membrane organizationISS:UniProtKB
Intestinal stem cell homeostasisISS:UniProtKB
Lipid modificationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of inflammatory responseISS:UniProtKB
Negative regulation of response to endoplasmic reticulum stressISS:UniProtKB
Phosphatidylcholine acyl-chain remodelingManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylcholine biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylethanolamine acyl-chain remodelingManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylserine acyl-chain remodelingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of intestinal cholesterol absorptionISS:UniProtKB
Positive regulation of sterol regulatory element binding protein cleavageISS:UniProtKB
Positive regulation of triglyceride transportISS:UniProtKB
Regulation of cholesterol biosynthetic processISS:UniProtKB
Very-low-density lipoprotein particle assemblyISS:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
More Infomation

Inagaki, N. F., Nakanishi, H., Ohto, T., Shindou, H., & Shimizu, T. (2024). LPCAT3/LPLAT12 deficiency in the liver ameliorates acetaminophen‐induced acute liver injury. The FASEB Journal, 38(1), e23328.

Cui, J., Wang, Y., Tian, X., Miao, Y., Ma, L., Zhang, C., ... & Zhang, X. (2023). LPCAT3 is transcriptionally regulated by YAP/ZEB/EP300 and collaborates with ACSL4 and YAP to determine ferroptosis sensitivity. Antioxidants & redox signaling, 39(7-9), 491-511.

Hu, J., Deng, Y., Ding, T., Dong, J., Liang, Y., & Lou, B. (2023). Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation: Lpcat3 deficiency promotes adipocyte inflammation. Acta Biochimica et Biophysica Sinica, 55(1), 117.

Lagrost, L., & Masson, D. (2022). The expanding role of lyso-phosphatidylcholine acyltransferase-3 (LPCAT3), a phospholipid remodeling enzyme, in health and disease. Current Opinion in Lipidology, 33(3), 193-198.

Reed, A., Ichu, T. A., Milosevich, N., Melillo, B., Schafroth, M. A., Otsuka, Y., ... & Cravatt, B. F. (2022). LPCAT3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosis. ACS Chemical Biology, 17(6), 1607-1618.

Shao, G., Qian, Y., Lu, L., Liu, Y., Wu, T., Ji, G., & Xu, H. (2022). Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer. Journal of Cancer, 13(8), 2430.

Ding, Y., Cui, K., Han, S., Hao, T., Liu, Y., Lai, W., ... & Ai, Q. (2022). Lysophosphatidylcholine acyltransferase 3 (LPCAT3) mediates palmitate-induced inflammation in macrophages of large yellow croaker (Larimichthys crocea). Fish & Shellfish Immunology, 126, 12-20.

Ichu, T. A., Reed, A., Ogasawara, D., Ulanovskaya, O., Roberts, A., Aguirre, C. A., ... & Cravatt, B. F. (2020). ABHD12 and LPCAT3 interplay regulates a lyso-phosphatidylserine-C20: 4 phosphatidylserine lipid network implicated in neurological disease. Biochemistry, 59(19), 1793-1799.

Liu, N., Sun, Q., Xu, H., Yu, X., Chen, W., Wei, H., ... & Lu, W. (2020). Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver. The FASEB Journal, 34(10), 13474-13493.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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