Mouse Anti-MAPK14 Recombinant Antibody (A1003) (CBMAB-AP4376LY)

Mouse

Human, Mouse, Rat

A1003

IgG

ELISA, IHC

Synthetic Peptide of P38

Human, Mouse, Rat

IgG

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

Affinity purity

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinase P38 Alpha; MAX-Interacting Protein 2; CSAID-Binding Protein; MAP Kinase P38 Alpha; P38 MAP Kinase; MAP Kinase 14; EC 2.7.11.24; SAPK2A; CSBP1; CSBP2; CSPB1; CSBP; Mxi2; Cytokine Suppressive Anti-Inflammatory Drug Binding Protein; Cytokine Suppressive Anti-Inflammatory Drug-Binding Protein;

CSB-MA626776

3'-UTR-mediated mRNA stabilizationManual Assertion Based On ExperimentTAS:UniProtKB
AngiogenesisIEA:Ensembl
Apoptotic processIEA:UniProtKB-KW
Bone developmentIEA:Ensembl
Cartilage condensationIEA:Ensembl
Cell morphogenesisIEA:Ensembl
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to ionizing radiationManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Cellular response to lipoteichoic acidManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to tumor necrosis factorIEA:Ensembl
Cellular response to vascular endothelial growth factor stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to virusManual Assertion Based On ExperimentIMP:UniProtKB
Cellular senescenceTAS:Reactome
ChemotaxisManual Assertion Based On ExperimentTAS:ProtInc
Chondrocyte differentiationIEA:Ensembl
DNA damage checkpoint signalingIEA:Ensembl
Fatty acid oxidationIEA:Ensembl
Glucose metabolic processIEA:Ensembl
Intracellular signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Lipopolysaccharide-mediated signaling pathwayIEA:Ensembl
Negative regulation of canonical Wnt signaling pathwayIEA:Ensembl
Negative regulation of hippo signalingManual Assertion Based On ExperimentIMP:FlyBase
Negative regulation of inflammatory response to antigenic stimulusTAS:Reactome
Osteoblast differentiationIEA:Ensembl
Osteoclast differentiationISS:BHF-UCL
p38MAPK cascadeISS:UniProtKB
Peptidyl-serine phosphorylationISS:BHF-UCL
Placenta developmentIEA:Ensembl
Platelet activationTAS:Reactome
Positive regulation of brown fat cell differentiationIEA:Ensembl
Positive regulation of cardiac muscle cell proliferationIEA:Ensembl
Positive regulation of cyclase activityManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of erythrocyte differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of glucose importIEA:Ensembl
Positive regulation of interleukin-12 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of muscle cell differentiationTAS:Reactome
Positive regulation of myoblast differentiationISS:UniProtKB
Positive regulation of myoblast fusionISS:UniProtKB
Positive regulation of myotube differentiationISS:UniProtKB
Positive regulation of protein import into nucleusIEA:Ensembl
Positive regulation of reactive oxygen species metabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIDA:CACAO
Regulation of ossificationIEA:Ensembl
Regulation of synaptic membrane adhesionIEA:Ensembl
Regulation of transcription by RNA polymerase IIISS:UniProtKB
Response to dietary excessIEA:Ensembl
Response to insulinIEA:Ensembl
Response to muramyl dipeptideIEA:Ensembl
Response to muscle stretchIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Signal transduction in response to DNA damageManual Assertion Based On ExperimentIMP:BHF-UCL
Skeletal muscle tissue developmentIEA:Ensembl
Stress-induced premature senescenceManual Assertion Based On ExperimentIMP:BHF-UCL
Striated muscle cell differentiationIEA:Ensembl
Transmembrane receptor protein serine/threonine kinase signaling pathwayIEA:Ensembl
Vascular endothelial growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL

Cytoplasm
Nucleus

Dually phosphorylated on Thr-180 and Tyr-182 by the MAP2Ks MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. Dual phosphorylation can also be mediated by TAB1-mediated autophosphorylation. TCR engagement in T-cells also leads to Tyr-323 phosphorylation by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP16. PPM1D also mediates dephosphorylation and inactivation of MAPK14 (PubMed:21283629).
Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases the affinity for ATP and enhances kinase activity. Lys-53 and Lys-152 are deacetylated by HDAC3.
Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway.