Rabbit Anti-MAPK8 Recombinant Antibody (A1012) (CBMAB-AP11672LY)

Mitogen-Activated Protein Kinase 8

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

Mitogen-Activated Protein Kinase 8; Stress-Activated Protein Kinase 1c; C-Jun N-Terminal Kinase 1; JUN N-Terminal Kinase; MAP Kinase 8; EC 2.7.11.24; JNK-46; SAPK1c; PRKM8; SAPK1; JNK1;

A11119

Cellular response to amino acid starvationManual Assertion Based On ExperimentIDA:CAFA
Cellular response to cadmium ionManual Assertion Based On ExperimentIMP:CAFA
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Cellular response to mechanical stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Cellular response to reactive oxygen speciesManual Assertion Based On ExperimentIMP:CAFA
Cellular senescenceTAS:Reactome
Fc-epsilon receptor signaling pathwayTAS:Reactome
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
JUN phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein bindingManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-threonine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell killingTAS:Reactome
Positive regulation of cyclase activityManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of deacetylase activityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTAS:Reactome
Positive regulation of protein metabolic processManual Assertion Based On ExperimentIMP:CACAO
Protein phosphorylationManual Assertion Based On ExperimentIDA:CAFA
Regulation of circadian rhythmISS:UniProtKB
Regulation of DNA replication origin bindingManual Assertion Based On ExperimentIMP:CAFA
Regulation of DNA-binding transcription factor activityTAS:Reactome
Regulation of macroautophagyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Regulation of protein localizationManual Assertion Based On ExperimentIDA:BHF-UCL
Response to mechanical stimulusManual Assertion Based On ExperimentIBA:GO_Central
Response to oxidative stressManual Assertion Based On ExperimentIDA:UniProtKB
Response to UVManual Assertion Based On ExperimentIDA:MGI
Rhythmic processIEA:UniProtKB-KW
Stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:CAFA

Cytoplasm
Nucleus
Cell junction, synapse
In the cortical neurons, predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity).
Colocalizes with POU5F1 in the nucleus.

Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme (PubMed:11062067).
Phosphorylated by TAOK2 (PubMed:17158878).
May be phosphorylated at Thr-183 and Tyr-185 by MAP3K1/MEKK1 (PubMed:17761173).
Phosphorylated form is more concentrated at synapses than none-phosphorylated (By similarity).