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Mouse Anti-MCM6 (AA 670-792) Recombinant Antibody (1/MCM6) (CBMAB-M2081-FY)

This product is mouse antibody that recognizes MCM6. The antibody 1/MCM6 can be used for immunoassay techniques such as: WB, Bioimaging.
See all MCM6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1/MCM6
Antibody Isotype
IgG1
Application
WB, Bioimaging

Basic Information

Immunogen
Human MCM6 aa. 670-792
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.25 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 670-792

Target

Full Name
minichromosome maintenance complex component 6
Introduction
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.
Entrez Gene ID
4175
UniProt ID
Q14566
Alternative Names
Minichromosome Maintenance Complex Component 6; Minichromosome Maintenance Deficient (Mis5, S. Pombe) 6; P105MCM; MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe) (S. Cerevisiae); MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe); Minichromosome Maintenance Deficient 6 Homolog (S. Cerevisiae)
Function
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Biological Process
DNA replication Source: UniProtKB
DNA replication initiation Source: InterPro
DNA unwinding involved in DNA replication Source: ComplexPortal
Double-strand break repair via break-induced replication Source: GO_Central
Mitotic DNA replication Source: GO_Central
Regulation of DNA-dependent DNA replication initiation Source: ComplexPortal
Cellular Location
Nucleus
Other locations
Chromosome
Note: Binds to chromatin during G1 and detach from it during S phase.
PTM
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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