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Mouse Anti-MIEF1 Recombinant Antibody (CBXS-2032) (CBMAB-S4799-CQ)

This product is a mouse antibody that recognizes MIEF1. The antibody CBXS-2032 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MIEF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2032
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mitochondrial Elongation Factor 1
Entrez Gene ID
54471
UniProt ID
L0R8F8
Alternative Names
Mitochondrial Elongation Factor 1; Smith-Magenis Syndrome Chromosomal Region Candidate Gene 7 Protein-Like; Smith-Magenis Syndrome Chromosome Region, Candidate 7-Like; Mitochondrial Dynamics Protein Of 51 KDa; SMCR7-Like Protein; SMCR7L; MID51;
Function
Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.
Biological Process
Cellular response to hypoxia Source: Ensembl
Mitochondrial fission Source: UniProtKB
Positive regulation of mitochondrial fission Source: UniProtKB
Positive regulation of protein targeting to membrane Source: UniProtKB
Cellular Location
Mitochondrion outer membrane
Topology
Mitochondrial intermembrane: 1-23
Helical: 24-46
Cytoplasmic: 47-463

Lin, Y., Wu, X., Lin, L., Mei, Y., Zhou, J., Chen, C., ... & Li, G. (2023). miR-494-5p mediates the antioxidant activity of EPA by targeting the mitochondrial elongation factor 1 gene MIEF1 in HepG2 cells. The Journal of Nutritional Biochemistry, 115, 109279.

Yu, R., Liu, T., Jin, S. B., Ankarcrona, M., Lendahl, U., Nistér, M., & Zhao, J. (2021). MIEF1/2 orchestrate mitochondrial dynamics through direct engagement with both the fission and fusion machineries. BMC biology, 19(1), 1-22.

Yu, R., Jin, S. B., Ankarcrona, M., Lendahl, U., Nistér, M., & Zhao, J. (2021). The molecular assembly state of Drp1 controls its association with the mitochondrial recruitment receptors mff and MIEF1/2. Frontiers in Cell and Developmental Biology, 9, 706687.

Charif, M., Wong, Y. C., Kim, S., Guichet, A., Vignal, C., Zanlonghi, X., ... & Lenaers, G. (2021). Dominant mutations in MIEF1 affect mitochondrial dynamics and cause a singular late onset optic neuropathy. Molecular neurodegeneration, 16, 1-9.

Zhang, Y., Wang, M., Xu, X., Liu, Y., & Xiao, C. (2019). Matrine promotes apoptosis in SW480 colorectal cancer cells via elevating MIEF1‐related mitochondrial division in a manner dependent on LATS2‐hippo pathway. Journal of Cellular Physiology, 234(12), 22731-22741.

Xian, H., & Liou, Y. C. (2019). Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy. Autophagy, 15(12), 2107-2125.

Lu, K., Liu, X., & Guo, W. (2019). Melatonin attenuates inflammation‐related venous endothelial cells apoptosis through modulating the MST1–MIEF1 pathway. Journal of Cellular Physiology, 234(12), 23675-23684.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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