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Mouse Anti-MPHOSPH9 Recombinant Antibody (CBFYM-2490) (CBMAB-M2677-FY)

This product is mouse antibody that recognizes MPHOSPH9. The antibody CBFYM-2490 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all MPHOSPH9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2490
Antibody Isotype
IgG2a, k
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
M-phase phosphoprotein 9
Introduction
MPHOSPH9 is a Protein Coding gene.
Entrez Gene ID
10198
UniProt ID
Q99550
Alternative Names
M-Phase Phosphoprotein 9; MPP9; MPP-9
Function
Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385).

At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385).
Biological Process
Negative regulation of cilium assembly Source: UniProtKB
Cellular Location
Cytoskeleton
centriole
centrosome
Golgi apparatus
Golgi apparatus membrane
Note: Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole (PubMed:21399614). Recruited by KIF24 to the distal end of mother centriole where it forms a ring-like structure (PubMed:30375385).
PTM
TTBK2-mediated phosphorylation at Ser-629 and Ser-636, promotes its ubiquitination at Lys-632 leading to proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Phosphorylated in M (mitotic) phase (PubMed:8885239).
Ubiquitinated at Lys-632, leading to proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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