Mouse Anti-MRPS2 Recombinant Antibody (CBFYM-2575) (CBMAB-M2763-FY)

Name: Mouse Anti-MRPS2 Recombinant Antibody (CBFYM-2575)
SKU: CBMAB-M2763-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2575

Application

FC, IHC-P, WB

Immunogen

Full length human recombinant protein of human MRPS2 (NP_057118) produced in E. coli

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MITOCHONDRIAL RIBOSOMAL PROTEIN S2

Introduction

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene.

Entrez Gene ID

51116

UniProt ID

Q9Y399

Alternative Names

Mitochondrial Ribosomal Protein S2; Mitochondrial Small Ribosomal Subunit Protein US2m; MRP-S2; S2mt; 28S Ribosomal Protein S2, Mitochondrial; CGI-91

Function

Required for mitoribosome formation and stability, and mitochondrial translation.

Biological Process

Mitochondrial ribosome assembly Source: UniProtKB
Mitochondrial translation Source: UniProtKB

Cellular Location

Mitochondrion

Involvement in disease

Combined oxidative phosphorylation deficiency 36 (COXPD36):
An autosomal recessive, multisystem disease resulting from deficiencies of mitochondrial respiratory enzyme complexes and mitochondrial dysfunction. Clinical manifestations include sensorineural hearing impairment, mild developmental delay, hypoglycemia, and intellectual disability.

Papadopoulos, T., Gaignard, P., Schiff, M., Rio, M., Karall, D., Legendre, A., ... & Ruaud, L. (2023). New description of an MRPS2 homozygous patient: Further features to help expend the phenotype. European Journal of Medical Genetics, 104889.

Liu, C., Zhou, W., Liu, Q., & Peng, Z. (2022). Hypoglycemia with lactic acidosis caused by a new MRPS2 gene mutation in a Chinese girl: A case report. BMC Endocrine Disorders, 22(1), 1-4.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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