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Mouse Anti-MRPS2 Recombinant Antibody (CBFYM-2575) (CBMAB-M2763-FY)

This product is mouse antibody that recognizes MRPS2. The antibody CBFYM-2575 can be used for immunoassay techniques such as: FC, IHC-P, WB.
See all MRPS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2575
Antibody Isotype
IgG2a
Application
FC, IHC-P, WB

Basic Information

Immunogen
Full length human recombinant protein of human MRPS2 (NP_057118) produced in E. coli
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MITOCHONDRIAL RIBOSOMAL PROTEIN S2
Introduction
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene.
Entrez Gene ID
51116
UniProt ID
Q9Y399
Alternative Names
Mitochondrial Ribosomal Protein S2; Mitochondrial Small Ribosomal Subunit Protein US2m; MRP-S2; S2mt; 28S Ribosomal Protein S2, Mitochondrial; CGI-91
Function
Required for mitoribosome formation and stability, and mitochondrial translation.
Biological Process
Mitochondrial ribosome assembly Source: UniProtKB
Mitochondrial translation Source: UniProtKB
Cellular Location
Mitochondrion
Involvement in disease
Combined oxidative phosphorylation deficiency 36 (COXPD36):
An autosomal recessive, multisystem disease resulting from deficiencies of mitochondrial respiratory enzyme complexes and mitochondrial dysfunction. Clinical manifestations include sensorineural hearing impairment, mild developmental delay, hypoglycemia, and intellectual disability.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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