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Mouse Anti-MSX1 (AA 216-297) Recombinant Antibody (CBFYM-2693) (CBMAB-M2883-FY)

This product is mouse antibody that recognizes MSX1. The antibody CBFYM-2693 can be used for immunoassay techniques such as: ELISA, IP, WB.
See all MSX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2693
Antibody Isotype
IgG2a, k
Application
ELISA, IP, WB

Basic Information

Immunogen
Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: NRRAKAKRLQ EAELEKLKMA AKPMLPPAAF GLSFPLGGPA AVAAAAGASL YGASGPFQRA ALPVAPVGLY TAHVGYSMYH LT
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 216-297

Target

Full Name
Msh Homeobox 1
Introduction
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia.
Entrez Gene ID
4487
UniProt ID
P28360
Alternative Names
Msh Homeobox 1; Msh Homeobox 1-Like Protein; Homeobox Protein Hox-7; HOX7; Msh (Drosophila) Homeo Box Homolog 1 (Formerly Homeo Box 7); Msh Homeobox Homolog 1 (Drosophila); Homeobox Protein MSX-1
Function
Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.
Biological Process
Activation of meiosis Source: Ensembl
Anterior/posterior pattern specification Source: Ensembl
BMP signaling pathway involved in heart development Source: Ensembl
Bone morphogenesis Source: Ensembl
Cardiac conduction system development Source: BHF-UCL
Cartilage morphogenesis Source: Ensembl
Cell morphogenesis Source: BHF-UCL
Embryonic forelimb morphogenesis Source: Ensembl
Embryonic hindlimb morphogenesis Source: Ensembl
Embryonic morphogenesis Source: GO_Central
Embryonic nail plate morphogenesis Source: BHF-UCL
Epithelial to mesenchymal transition involved in endocardial cushion formation Source: Ensembl
Face morphogenesis Source: BHF-UCL
Forebrain development Source: Ensembl
In utero embryonic development Source: Ensembl
Mammary gland epithelium development Source: Ensembl
Mesenchymal cell proliferation Source: Ensembl
Midbrain development Source: Ensembl
Middle ear morphogenesis Source: Ensembl
Muscle organ development Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell growth Source: BHF-UCL
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of striated muscle cell differentiation Source: Ensembl
Negative regulation of transcription regulatory region DNA binding Source: Ensembl
Odontogenesis of dentin-containing tooth Source: BHF-UCL
Positive regulation of BMP signaling pathway Source: Ensembl
Positive regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: BHF-UCL
Positive regulation of mesenchymal cell apoptotic process Source: Ensembl
Protein localization to nucleus Source: BHF-UCL
Protein stabilization Source: BHF-UCL
Regulation of odontogenesis Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Roof of mouth development Source: Ensembl
Signal transduction involved in regulation of gene expression Source: Ensembl
Stem cell differentiation Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Tooth agenesis, selective, 1 (STHAG1):
A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG1 can be associated with orofacial cleft in some patients.
Ectodermal dysplasia 3, Witkop type (ECTD3):
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. ECTD3 is characterized by abnormalities largely limited largely to teeth (some of which are missing) and nails (which are poorly formed early in life, especially toenails). This condition is distinguished from anhidrotic ectodermal dysplasia by autosomal dominant inheritance and little involvement of hair and sweat glands. The teeth are not as severely affected.
Non-syndromic orofacial cleft 5 (OFC5):
A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
PTM
Sumoylated by PIAS1, desumoylated by SENP1.

Zhou, G., Ma, S., Yang, M., & Yang, Y. (2022). Global Quantitative Proteomics Analysis Reveals the Downstream Signaling Networks of Msx1 and Msx2 in Myoblast Differentiation. Phenomics, 2(3), 201-210.

Singh, S., Biswas, S., Srivastava, A., Mishra, Y., & Chaturvedi, T. P. (2021). In silico characterization and structural modeling of a homeobox protein MSX1 from homo sapiens. Informatics in Medicine Unlocked, 22, 100497.

Kwon, D. H., Choe, N., Shin, S., Ryu, J., Kim, N., Eom, G. H., ... & Kook, H. (2021). Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2. Experimental & Molecular Medicine, 53(11), 1781-1791.

Olsson, B., Calixto, R. D., da Silva Machado, N. C., Meger, M. N., Paula-Silva, F. W. G. D., Rebellato, N. L. B., ... & Scariot, R. (2020). MSX1 is differentially expressed in the deepest impacted maxillary third molars. British Journal of Oral and Maxillofacial Surgery, 58(7), 789-794.

Yang, Y., Zhu, X., Jia, X., Hou, W., Zhou, G., Ma, Z., ... & Wang, G. (2020). Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development. Nucleic Acids Research, 48(20), 11452-11467.

Horazna, M., Janeckova, L., Svec, J., Babosova, O., Hrckulak, D., Vojtechova, M., ... & Korinek, V. (2019). Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium. Scientific Reports, 9(1), 1629.

Mártha, K., Kerekes Máthé, B., Moldovan, V. G., & Bănescu, C. (2019). Study of rs12532, rs8670 polymorphism of Msh homeobox 1 (MSX1), rs61754301, rs4904155 polymorphism of paired box gene 9 (PAX9), and rs2240308 polymorphism of axis inhibitor protein 2 (AXIN2) genes in nonsyndromic hypodontia. BioMed Research International, 2019.

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For research use only. Not intended for any clinical use.

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