Mouse Anti-MTMR14 Recombinant Antibody (CBFYM-2747) (CBMAB-M2940-FY)

Name: Mouse Anti-MTMR14 Recombinant Antibody (CBFYM-2747)
SKU: CBMAB-M2940-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2747

Application

FC, IF, WB

Immunogen

MTMR14 antibody was raised in mouse using a full length recombinant protein of human MTMR14 (NP_001070993) produced in HEK293T cells,

Specificity

Human, Dog, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

myotubularin related protein 14

Introduction

This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18.

Entrez Gene ID

Human	64419
Dog	484668
Rat	312634

UniProt ID

Human	Q8NCE2
Dog	E2RB77
Rat	D3ZMA2

Alternative Names

Myotubularin Related Protein 14; HCV NS5A-Transactivated Protein 4 Splice Variant A-Binding Protein 1; NS5ATP4ABP1; C3orf29; Egg-Derived Tyrosine Phosphatase Homolog (Drosophila); Egg-Derived Tyrosine Phosphatase Homolog

Function

Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.

Biological Process

Macroautophagy Source: Reactome
Phosphatidylinositol biosynthetic process Source: Reactome

Cellular Location

Cytoplasm
Note: Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.

Involvement in disease

Myopathy, centronuclear, 1 (CNM1):
A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.

Su, Y., Yu, F., Wang, C., & Wan, P. (2023). MTMR14 as a novel prognostic predictor and potential immunotherapy target in uveal melanoma.

Gu, Y., Chen, J., Huang, Q., Zhan, Y., Wang, T., Wu, J., ... & Xie, J. (2022). MTMR14 alleviates chronic obstructive pulmonary disease as a regulator in inflammation and emphysema. Oxidative Medicine and Cellular Longevity, 2022.

Li, S., Zhang, M., & Zhang, B. (2020). MTMR14 protects against hepatic ischemia-reperfusion injury through interacting with AKT signaling in vivo and in vitro. Biomedicine & Pharmacotherapy, 129, 110455.

Pan, Q., Liu, Y., Wang, G., Wen, Z., & Wang, Y. (2020). MTMR14 protects against cerebral stroke through suppressing PTEN-regulated autophagy. Biochemical and Biophysical Research Communications, 529(4), 1045-1052.

Xiao, C., Qiu, S., Li, X., Luo, D. J., & Liu, G. P. (2019). EDTP/MTMR14: A novel target for improved survivorship to prolonged anoxia and cellular protein aggregates. Neuroscience Letters, 705, 151-158.

Li, Z., Rong, L., Lian, H., Cheng, J., Wu, X., & Li, X. (2019). Knockdown MTMR14 promotes cell apoptosis and inhibits migration in liver cancer cells. Gene, 691, 106-113.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-MTMR14 (AA 1-417) Recombinant Antibody (CBFYM-2746) (CAT#: CBMAB-M2939-FY)

Isotype control

For research use only. Not intended for any clinical use.

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