Mouse Anti-MYC Recombinant Antibody (CBYY-C2692) (CBMAB-C4133-YY)

Mouse

Human, Mouse, Rat, Chicken

CBYY-C2692

IgG1

IF, IP, WB

C-myc antibody was raised in mouse using recombinant c-myc protein as the immunogen

Human, Mouse, Rat, Chicken

IgG1

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Protein A purified

PBS, pH 7.4, 0.2% BSA

Liquid

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Platelet And Endothelial Cell Adhesion Molecule 1; CD31 Antigen; EndoCAM; PECAM-1; GPIIA; PECA1;

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).

Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).

Beta-catenin-TCF complex assembly Source: Reactome
Branching involved in ureteric bud morphogenesis Source: UniProtKB
Cell cycle arrest Source: UniProtKB
Cellular iron ion homeostasis Source: UniProtKB
Cellular response to DNA damage stimulus Source: UniProtKB
Cellular response to drug Source: UniProtKB
Cellular response to hypoxia Source: CAFA
Cellular response to UV Source: UniProtKB
Chromatin remodeling Source: UniProtKB
Chromosome organization Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Energy reserve metabolic process Source: UniProtKB
ERK1 and ERK2 cascade Source: CAFA
Fibroblast apoptotic process Source: UniProtKB
G1/S transition of mitotic cell cycle Source: Reactome
MAPK cascade Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cell division Source: UniProtKB
Negative regulation of fibroblast proliferation Source: UniProtKB
Negative regulation of monocyte differentiation Source: UniProtKB
Negative regulation of stress-activated MAPK cascade Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Notch signaling pathway Source: Reactome
Oxygen transport Source: UniProtKB
Positive regulation of cell population proliferation Source: CAFA
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Positive regulation of DNA biosynthetic process Source: UniProtKB
Positive regulation of DNA methylation Source: BHF-UCL
Positive regulation of epithelial cell proliferation Source: UniProtKB
Positive regulation of fibroblast proliferation Source: UniProtKB
Positive regulation of gene expression Source: CAFA
Positive regulation of mesenchymal cell proliferation Source: UniProtKB
Positive regulation of metanephric cap mesenchymal cell proliferation Source: UniProtKB
Positive regulation of response to DNA damage stimulus Source: UniProtKB
Positive regulation of telomerase activity Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Protein deubiquitination Source: Reactome
Protein-DNA complex disassembly Source: CAFA
Regulation of gene expression Source: MGI
Regulation of somatic stem cell population maintenance Source: UniProtKB
Regulation of telomere maintenance Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to drug Source: UniProtKB
Response to gamma radiation Source: UniProtKB
Response to growth factor Source: UniProtKB

Nucleoplasm; Nucleolus

A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
Burkitt lymphoma (BL):
The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass.

Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.
Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28 but by USP36, due to the lack of interaction between isoform 3 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus (PubMed:25775507,PubMed:17558397). Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).