Mouse Anti-MYOCD (AA 97-290) Recombinant Antibody (CBFYM-2999) (CBMAB-M3194-FY)

Mouse

Human, Mouse

CBFYM-2999

IgG2b

WB

E. coli-derived recombinant human Myocardin, Met97-Leu290

Human, Mouse

IgG2b

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Lyophilized

PBS

LYOPH

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

AA 97-290

This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Myocardin; MYCD

Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).

Cardiac muscle cell differentiation Source: BHF-UCL
Cardiac ventricle development Source: Ensembl
Cardiocyte differentiation Source: UniProtKB
Cellular component maintenance Source: Ensembl
Digestive tract development Source: Ensembl
Ductus arteriosus closure Source: Ensembl
Lung alveolus development Source: Ensembl
Negative regulation of amyloid-beta clearance Source: BHF-UCL
Negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
Negative regulation of cell adhesion molecule production Source: Ensembl
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Negative regulation of myotube differentiation Source: Ensembl
Negative regulation of platelet-derived growth factor receptor-beta signaling pathway Source: Ensembl
Negative regulation of skeletal muscle cell differentiation Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Negative regulation of vascular associated smooth muscle cell migration Source: Ensembl
Negative regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
Positive regulation of cardiac muscle cell differentiation Source: BHF-UCL
Positive regulation of cardiac vascular smooth muscle cell differentiation Source: BHF-UCL
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of DNA binding Source: Ensembl
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of miRNA transcription Source: Ensembl
Positive regulation of smooth muscle cell differentiation Source: BHF-UCL
Positive regulation of smooth muscle contraction Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: BHF-UCL
Positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: BHF-UCL
Positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
Regulation of cell growth by extracellular stimulus Source: Ensembl
Regulation of histone acetylation Source: UniProtKB
Regulation of myoblast differentiation Source: Ensembl
Regulation of phenotypic switching Source: Ensembl
Regulation of smooth muscle cell differentiation Source: BHF-UCL
Response to hypoxia Source: BHF-UCL
Smooth muscle cell differentiation Source: BHF-UCL
Urinary bladder development Source: UniProtKB
Uterus development Source: Ensembl
Vascular associated smooth muscle cell differentiation Source: Ensembl
Vasculogenesis Source: Ensembl
Ventricular cardiac muscle cell differentiation Source: Ensembl

Nucleus

Megabladder, congenital (MGBL):
An autosomal dominant congenital anomaly characterized by a massively dilated urinary bladder with disrupted smooth muscle in the bladder wall. MGBL is a sex-limited trait with 95% male predominance, and incomplete penetrance. Affected males frequently die in utero.

Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity.