Mouse Anti-NCR1 Recombinant Antibody (CBT2453) (V2LY-0625-LY1014)

Name: Mouse Anti-NCR1 Recombinant Antibody (CBT2453)
SKU: V2LY-0625-LY1014
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT2453

Antibody Isotype

IgG1

Application

Basic Information

Immunogen

Purified recombinant fragment of human CD335 (AA: extra 22-258) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Natural Cytotoxicity Triggering Receptor 1

Entrez Gene ID

9437

UniProt ID

O76036

Function

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Biological Process

Cellular defense response Source: ProtInc
Natural killer cell activation Source: UniProtKB
Regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
Signal transduction Source: ProtInc

Topology

Extracellular: 22-258
Helical: 259-279
Cytoplasmic: 280-304

PTM

N-glycosylated.
O-glycosylated.

More Infomation

References

Imširović, V., Lenartić, M., Wensveen, F. M., Polić, B., & Jelenčić, V. (2023). Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness. Frontiers in Immunology, 14.

Pallmer, K., Barnstorf, I., Baumann, N. S., Borsa, M., Jonjic, S., & Oxenius, A. (2019). NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection. PLoS pathogens, 15(4), e1007725.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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