Mouse Anti-OPA3 Recombinant Antibody (CBXO-0473) (CBMAB-O0470-CQ)

Name: Mouse Anti-OPA3 Recombinant Antibody (CBXO-0473)
SKU: CBMAB-O0470-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXO-0473

Application

WB, IHC

Immunogen

Full length human Recombinant protein of human OPA3(NP_079412) produced in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, containing 1% BSA, 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

10 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

OPA3, Outer Mitochondrial Membrane Lipid Metabolism Regulator

Introduction

The mouse ortholog of this protein co-purifies with the mitochondrial inner membrane. Mutations in this gene have been shown to result in 3-methylglutaconic aciduria type III and autosomal dominant optic atrophy and cataract. Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

80207

UniProt ID

Q9H6K4

Alternative Names

OPA3, Outer Mitochondrial Membrane Lipid Metabolism Regulator; Optic Atrophy 3 (Autosomal Recessive, With Chorea And Spastic Paraplegia); Optic Atrophy 3 (Iraqi-Jewish Optic Atrophy Plus); Optic Atrophy 3 Protein; MGA3

Function

May play some role in mitochondrial processes.

Biological Process

Regulation of lipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Response to stimulusIEA:UniProtKB-KW
Visual perceptionManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Mitochondrion

Involvement in disease

3-methylglutaconic aciduria 3 (MGCA3):
An autosomal recessive metabolic disorder that causes a neuro-ophthalmologic syndrome consisting of early-onset bilateral optic atrophy, spasticity, extrapyramidal dysfunction and cognitive deficit. Urinary excretion of 3-methylglutaconic acid and 3-methylglutaric acid is increased. MGCA3 can be distinguished from MGCA1 by the absence of increase of 3-hydroxyisovaleric acid levels.
Optic atrophy 3 (OPA3):
A condition that features progressive visual loss in association with optic atrophy. Atrophy of the optic disk indicates a deficiency in the number of nerve fibers which arise in the retina and converge to form the optic disk, optic nerve, optic chiasm and optic tracts. OPA3 is associated with cataract and a neurologic disorder characterized by extrapyramidal signs and ataxia.

Narwal, M., Jain, S., Rathore, S., & Mohmmed, A. (2023). Plasmodium falciparum OPA3‐like protein (Pf OPA3) is essential for maintenance of mitochondrial homeostasis and parasite proliferation. The FASEB Journal, 37(11), e23235.

Tsai, H. W., Li, C. J., Lin, L. T., Chiang, A. J., Chen, S. N., Wen, Z. H., & Tsui, K. H. (2022). Expression status and prognostic significance of mitochondrial dynamics OPA3 in human ovarian cancer. Aging (Albany NY), 14(9), 3874.

Meng, N., Glorieux, C., Zhang, Y., Liang, L., Zeng, P., Lu, W., & Huang, P. (2019). Oncogenic K-ras induces mitochondrial OPA3 expression to promote energy metabolism in pancreatic cancer cells. Cancers, 12(1), 65.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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