Mouse Anti-PCDH8 Recombinant Antibody (6A8) (CBMAB-P0980-YC)

Name: Mouse Anti-PCDH8 Recombinant Antibody (6A8)
SKU: CBMAB-P0980-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6A8

Application

Immunogen

PCDH8 (NP_002581, 32-121 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

protocadherin 8

Introduction

PCDH8 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.

Entrez Gene ID

5100

UniProt ID

O95206

Alternative Names

Protocadherin 8; ARCADLIN; Protocadherin-8; PAPC;

Function

Calcium-dependent cell-adhesion protein (By similarity).
May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity).
Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity).

Biological Process

Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Chemical synaptic transmissionIEA:Ensembl
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:InterPro
Morphogenesis of embryonic epitheliumIEA:Ensembl
Regulation of synaptic membrane adhesionIEA:Ensembl
SomitogenesisIEA:Ensembl

Cellular Location

Cell membrane
Cell projection, dendrite
Cell junction, synapse, presynaptic cell membrane
Cell junction, synapse, postsynaptic cell membrane
Also expressed in neuronal cell bodies. Localized to excitatory, but not with inhibitory, synapses.

Topology

Extracellular: 30-749
Helical: 750-770
Cytoplasmic: 771-1070

Yang, R., Yang, N., Yin, P., Xue, Z., Sun, F., Fan, R., ... & Sun, L. (2024). PCDH8 is a novel prognostic biomarker in thyroid cancer and promotes cell proliferation and viability. Functional & Integrative Genomics, 24(2), 1-19.

Wei, H., Wu, Y., Zhuang, H., & Su, H. (2023). PCDH8 protects MPP+-induced neuronal injury in SH-SY5Y cells by inhibiting MAPK pathway. Molecular & Cellular Toxicology, 19(2), 293-302.

Wu, S., Li, X., Yang, J., & Yang, L. (2022). PCDH8 participates in the growth process of colorectal cancer cells by regulating the AKT/GSK3β/β-catenin signaling pathway. Tissue and Cell, 78, 101864.

Ye, J., Liao, Q., Zeng, X., Liu, C., Ding, Y., Liu, X., ... & Yuan, Y. (2021). MicroRNA-124-3p inhibited progression of nasopharyngeal carcinoma by interaction with PCDH8 and the inactivation of PI3K/AKT/mTOR pathway. Journal of Cancer, 12(16), 4933.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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