Mouse Anti-PIGL Recombinant Antibody (2B6) (CBMAB-P1760-YC)

Name: Mouse Anti-PIGL Recombinant Antibody (2B6)
SKU: CBMAB-P1760-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2B6

Application

ELISA

Immunogen

PIGL (NP_004269, 153-252 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

phosphatidylinositol glycan anchor biosynthesis, class L

Introduction

PIGL is an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). Study of a similar rat enzyme suggests that this protein localizes to the endoplasmic reticulum.

Entrez Gene ID

9487

UniProt ID

Q9Y2B2

Alternative Names

Phosphatidylinositol Glycan Anchor Biosynthesis Class L; Phosphatidylinositol-Glycan Biosynthesis Class L Protein; N-Acetylglucosaminylphosphatidylinositol Deacetylase; Phosphatidylinositol Glycan, Class L; PIG-L; N-Acetylglucosaminyl-Phosphatidylinositol De-N-Acetylase; EC 3.5.1.89; CHIME;

Function

Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

Biological Process

GPI anchor biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Preassembly of GPI anchor in ER membraneTAS:Reactome

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Coloboma, congenital heart disease, ichthyosiform dermatosis, mental retardation and ear anomalies syndrome (CHIME):
An extremely rare autosomal recessive multisystem disorder clinically characterized by colobomas, congenital heart defects, migratory ichthyosiform dermatosis, mental retardation, and ear anomalies including conductive hearing loss. Other clinical features include distinctive facial features, abnormal growth, genitourinary abnormalities, seizures, and feeding difficulties.

Topology

Helical: 2-22
Cytoplasmic: 23-252

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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