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Mouse Anti-PIGL Recombinant Antibody (2B6) (CBMAB-P1760-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphatidylinositol Glycan Anchor Biosynthesis Class L. The antibody can be used for immunoassay techniques, such as ELISA.
See all PIGL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B6
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
PIGL (NP_004269, 153-252 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphatidylinositol glycan anchor biosynthesis, class L
Introduction
PIGL is an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). Study of a similar rat enzyme suggests that this protein localizes to the endoplasmic reticulum.
Entrez Gene ID
9487
UniProt ID
Q9Y2B2
Alternative Names
Phosphatidylinositol Glycan Anchor Biosynthesis Class L; Phosphatidylinositol-Glycan Biosynthesis Class L Protein; N-Acetylglucosaminylphosphatidylinositol Deacetylase; Phosphatidylinositol Glycan, Class L; PIG-L; N-Acetylglucosaminyl-Phosphatidylinositol De-N-Acetylase; EC 3.5.1.89; CHIME;
Function
Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.
Biological Process
GPI anchor biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Preassembly of GPI anchor in ER membraneTAS:Reactome
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Coloboma, congenital heart disease, ichthyosiform dermatosis, mental retardation and ear anomalies syndrome (CHIME):
An extremely rare autosomal recessive multisystem disorder clinically characterized by colobomas, congenital heart defects, migratory ichthyosiform dermatosis, mental retardation, and ear anomalies including conductive hearing loss. Other clinical features include distinctive facial features, abnormal growth, genitourinary abnormalities, seizures, and feeding difficulties.
Topology
Helical: 2-22
Cytoplasmic: 23-252
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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