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Mouse Anti-PIP5K1B Recombinant Antibody (F-4) (CBMAB-P1878-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PIP5K1B antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
F-4
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta
Introduction
PIP5K1B has broad expression in colon (RPKM 8.2), duodenum (RPKM 7.6) and 20 other tissues.
Entrez Gene ID
Human8395
Mouse18719
Rat309419
UniProt ID
HumanO14986
MouseP70181
RatQ5CZZ9
Alternative Names
Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta; Phosphatidylinositol 4-Phosphate 5-Kinase Type I Beta; Type I Phosphatidylinositol 4-Phosphate 5-Kinase Beta; PtdIns(4)P-5-Kinase 1 Beta; Protein STM-7; PIP5K1-Beta; EC 2.7.1.68;
Function
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity).
PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity).
Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity).
Biological Process
Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of phosphatidylinositol 3-kinase signalingTAS:Reactome
Cellular Location
Cytoplasm, cytosol
Cell membrane
Endomembrane system
Associated with membranes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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