Mouse Anti-PIP5K1B Recombinant Antibody (F-4) (CBMAB-P1878-YC)

Name: Mouse Anti-PIP5K1B Recombinant Antibody (F-4)
SKU: CBMAB-P1878-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

F-4

Application

WB, IP, IF, ELISA

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta

Introduction

PIP5K1B has broad expression in colon (RPKM 8.2), duodenum (RPKM 7.6) and 20 other tissues.

Entrez Gene ID

Human	8395
Mouse	18719
Rat	309419

UniProt ID

Human	O14986
Mouse	P70181
Rat	Q5CZZ9

Alternative Names

Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta; Phosphatidylinositol 4-Phosphate 5-Kinase Type I Beta; Type I Phosphatidylinositol 4-Phosphate 5-Kinase Beta; PtdIns(4)P-5-Kinase 1 Beta; Protein STM-7; PIP5K1-Beta; EC 2.7.1.68;

Function

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity).
PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity).
Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity).

Biological Process

Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of phosphatidylinositol 3-kinase signalingTAS:Reactome

Cellular Location

Cytoplasm, cytosol
Cell membrane
Endomembrane system
Associated with membranes.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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