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Mouse Anti-PMEPA1 Recombinant Antibody (2A12) (CBMAB-P2221-YC)

Provided herein is a Mouse monoclonal antibody against Human Prostate Transmembrane Protein, Androgen Induced 1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PMEPA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A12
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
TMEPAI (AAH15918, 181-280 aa) partial recombinant protein with GST tag. Immunogen sequence: NRTIFDSDLM DSARLGGPCP PSSNSGISAT CYGSGGRMEG PPPTYSEVIG HYPGSSFQHQ QSSGPPSLLE GTRLHHTHIA PLESAAIWSK EKDKQKGHPL
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 181-280

Target

Full Name
Prostate Transmembrane Protein, Androgen Induced 1
Introduction
PMEPA1 is a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins.
Entrez Gene ID
56937
UniProt ID
Q969W9
Alternative Names
TMEPAI; STAG1
Function
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487).
Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).
Biological Process
Androgen receptor signaling pathway1 PublicationNAS:UniProtKB
Negative regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of SMAD protein complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Early endosome membrane
Golgi apparatus membrane
Topology
Lumenal: 1-40
Helical: 41-63
Cytoplasmic: 64-287
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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