Mouse Anti-PPIA Recombinant Antibody (ZC001) (CBMAB-C12218-LY)

peptidylprolyl isomerase A (cyclophilin A)

Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:25678563, PubMed:21593166).
Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143).
Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913).
Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815).
In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369).
Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851).
Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563).
Plays an important role in platelet activation and aggregation (By similarity).
Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity).
Binds heparan sulfate glycosaminoglycans (PubMed:11943775).
Inhibits replication of influenza A virus (IAV) (PubMed:19207730).
Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:30328013, PubMed:22347431).
(Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292).
(Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner.

Activation of protein kinase B activityManual Assertion Based On ExperimentIDA:UniProtKB
Apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Cell adhesion molecule productionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to oxidative stressManual Assertion Based On ExperimentIDA:UniProtKB
Endothelial cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Leukocyte chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Lipid droplet organizationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein K48-linked ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of viral life cycleManual Assertion Based On ExperimentIMP:UniProtKB
Neuron differentiationIEA:Ensembl
Neutrophil chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Platelet activationISS:UniProtKB
Platelet aggregationISS:UniProtKB
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein secretionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of viral genome replicationManual Assertion Based On ExperimentIMP:UniProtKB
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein peptidyl-prolyl isomerizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of viral genome replicationManual Assertion Based On ExperimentIMP:UniProtKB
Viral release from host cellManual Assertion Based On ExperimentTAS:UniProtKB

Cytoplasm
Secreted
Nucleus
Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that includes Rho GTPase signaling, actin remodeling, and myosin II activation.

Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (PubMed:20364129, Ref.12). Acetylation at Lys-125 favors its interaction with TARDBP (PubMed:25678563).